8-hydroxyloxapine

Product Name: 8-hydroxyloxapine
CAS No.: 61443-77-4
Chemical Name: 8-hydroxyloxapine
Synonyms: 8-hydroxyloxapine;Loxapine 8-Hydroxy Impurity;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol;2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol;Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
CBNumber: CB11370570
Molecular Formula: C18H18ClN3O2
Formula Weight: 343.81
MOL File: 61443-77-4.mol

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8-hydroxyloxapine Property

Melting point:: 212-215°C
storage temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility: DMSO: soluble
form: A solid
Stability:: Light Sensitive

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21786
Product name: 8-hydroxy Loxapine
Purity: ≥98%
Packaging: 500μg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 21786
Product name: 8-hydroxy Loxapine
Purity: ≥98%
Packaging: 1mg
Price: $290
Updated: 2024/03/01

TRC

Product number: H943730
Product name: 8-HydroxyLoxapine
Packaging: 1mg
Price: $260
Updated: 2021/12/16

Usbiological

Product number: 013929
Product name: 8-Hydroxy Loxapine
Packaging: 1mg
Price: $566
Updated: 2021/12/16

AK Scientific

Product number: 3064CA
Product name: 8-Hydroxyloxapine
Packaging: 1mg
Price: $421
Updated: 2021/12/16

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8-hydroxyloxapine Chemical Properties,Usage,Production

Description

8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α₁-adrenergic receptors (K_i values = 7, 7.7, 9.5, 12, and 31 nM for H₁, 5-HT_2A, 5-HT_2C, D₂, and α_1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [¹⁴C]5-HT uptake in vitro (IC₅₀ = 2 μM in human platelets).

Chemical Properties

Pale Yellow Solid

Uses

The inactive

8-hydroxyloxapine Preparation Products And Raw materials

Raw materials

Preparation Products

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8-hydroxyloxapine Suppliers

Canada 1 China 8 United States 4 Global 13

J & K SCIENTIFIC LTD.

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BOC Sciences

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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Shanghai Yiyan Biotechnology Co. , Ltd.

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Shanghai Haohong Scientific Co., Ltd.

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Shanghai Yifei Biotechnology Co. , Ltd.

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61443-77-4, 8-hydroxyloxapineRelated Search:

8-METHOXY LOXAPINE 2-METHOXY-BENZAMIDINE HCL 1-(3-CHLOROBENZYL)PIPERAZINE 1-(2-METHOXYBENZYL) PIPERAZINE 4-(4-Chlorophenoxy)phenol 8-hydroxyloxapine CHEMBRDG-BB 4022460 Dibenz-(b,f)-1,4-oxazephine Amoxapine 1-(2-PHENOXYPHENYL)METHANAMINE HYDROCHLORIDE 2-Hydroxy-benzamidine HCl loxapine

8-hydroxyloxapine

2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol

8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol

Loxapine 8-Hydroxy Impurity

Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-

61443-77-4

Heterocycles

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals