8-hydroxyloxapine
- Product Name
- 8-hydroxyloxapine
- CAS No.
- 61443-77-4
- Chemical Name
- 8-hydroxyloxapine
- Synonyms
- 8-hydroxyloxapine;8-Hydroxy Loxapine solution;Loxapine 8-Hydroxy Impurity;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol;2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol;Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
- CBNumber
- CB11370570
- Molecular Formula
- C18H18ClN3O2
- Formula Weight
- 343.81
- MOL File
- 61443-77-4.mol
8-hydroxyloxapine Property
- Melting point:
- 212-215°C
- storage temp.
- Amber Vial, -20°C Freezer, Under Inert Atmosphere
- solubility
- DMSO: soluble
- form
- A solid
- Stability:
- Light Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21786
- Product name
- 8-hydroxy Loxapine
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 21786
- Product name
- 8-hydroxy Loxapine
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $290
- Updated
- 2024/03/01
- Product number
- H943730
- Product name
- 8-HydroxyLoxapine
- Packaging
- 1mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- 013929
- Product name
- 8-Hydroxy Loxapine
- Packaging
- 1mg
- Price
- $566
- Updated
- 2021/12/16
- Product number
- 3064CA
- Product name
- 8-Hydroxyloxapine
- Packaging
- 1mg
- Price
- $421
- Updated
- 2021/12/16
8-hydroxyloxapine Chemical Properties,Usage,Production
Description
8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).
Chemical Properties
Pale Yellow Solid
Uses
The inactive
References
[1] MD P S, PH.D Hubert H M V T Ph D Roy Corbett Ph D. Atypical Neuroleptics Have Low Affinity for Dopamine D2 Receptors or Are Selective for D4 Receptors[J]. Neuropsychopharmacology, 1997, 16 2: 93-110. DOI: 10.1016/s0893-133x(96)00187-x
[2] YIN CHEONG WONG Zhong Z Siu Kwan Wo. Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC–MS/MS[J]. Journal of pharmaceutical and biomedical analysis, 2012, 58: Pages 83-93. DOI: 10.1016/j.jpba.2011.09.020
[3] ANDREW J GOUDIE. H1-histamine Receptor Affinity Predicts Short-term Weight Gain for Typical and Atypical Antipsychotic Drugs[J]. Neuropsychopharmacology, 2003, 28 12: 2209-2209. DOI: 10.1038/sj.npp.1300291
[4] JUSTIN FADEN L C. Examining the safety, efficacy, and patient acceptability of inhaled loxapine for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults[J]. Neuropsychiatric Disease and Treatment, 2019, 15 1: 2273-2283. DOI: 10.2147/ndt.s173567
[5] A. FULTON G. D B T Norman. Ligand binding and platelet uptake studies of loxapine, amoxapine and their 8-hydroxylated derivatives[J]. Journal of affective disorders, 1982, 4 2: Pages 113-119. DOI: 10.1016/0165-0327(82)90041-6
8-hydroxyloxapine Preparation Products And Raw materials
Raw materials
Preparation Products
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