ChemicalBook > CAS DataBase List > 8-hydroxyloxapine

8-hydroxyloxapine

Product Name
8-hydroxyloxapine
CAS No.
61443-77-4
Chemical Name
8-hydroxyloxapine
Synonyms
8-hydroxyloxapine;Loxapine 8-Hydroxy Impurity;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol;2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol;Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
CBNumber
CB11370570
Molecular Formula
C18H18ClN3O2
Formula Weight
343.81
MOL File
61443-77-4.mol
More
Less

8-hydroxyloxapine Property

Melting point:
212-215°C
storage temp. 
Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility 
DMSO: soluble
form 
A solid
Stability:
Light Sensitive
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
21786
Product name
8-hydroxy Loxapine
Purity
≥98%
Packaging
500μg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
21786
Product name
8-hydroxy Loxapine
Purity
≥98%
Packaging
1mg
Price
$290
Updated
2024/03/01
TRC
Product number
H943730
Product name
8-HydroxyLoxapine
Packaging
1mg
Price
$260
Updated
2021/12/16
Usbiological
Product number
013929
Product name
8-Hydroxy Loxapine
Packaging
1mg
Price
$566
Updated
2021/12/16
AK Scientific
Product number
3064CA
Product name
8-Hydroxyloxapine
Packaging
1mg
Price
$421
Updated
2021/12/16
More
Less

8-hydroxyloxapine Chemical Properties,Usage,Production

Description

8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).

Chemical Properties

Pale Yellow Solid

Uses

The inactive

8-hydroxyloxapine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

8-hydroxyloxapine Suppliers

Canada 1 China 10 United States 5 Global 16
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Shanghai Yiyan Biotechnology Co. , Ltd.
Tel
021-69985186 13611928337
Email
3427709316@qq.com
Country
China
ProdList
7979
Advantage
58
Shanghai Haohong Scientific Co., Ltd.
Tel
400-400-8210725
Email
malulu@leyan.com
Country
China
ProdList
39990
Advantage
58
Cato Research Chemicals Inc.
Tel
13342851930
Email
3008394369@qq.com
Country
China
ProdList
15726
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

61443-77-4, 8-hydroxyloxapineRelated Search:

8-METHOXY LOXAPINE 2-METHOXY-BENZAMIDINE HCL 1-(3-CHLOROBENZYL)PIPERAZINE 1-(2-METHOXYBENZYL) PIPERAZINE 4-(4-Chlorophenoxy)phenol 8-hydroxyloxapine CHEMBRDG-BB 4022460 Dibenz-(b,f)-1,4-oxazephine Amoxapine 1-(2-PHENOXYPHENYL)METHANAMINE HYDROCHLORIDE 2-Hydroxy-benzamidine HCl loxapine

  • 8-hydroxyloxapine
  • 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol
  • 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol
  • Loxapine 8-Hydroxy Impurity
  • Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
  • 61443-77-4
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals