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8-hydroxyloxapine

Product Name
8-hydroxyloxapine
CAS No.
61443-77-4
Chemical Name
8-hydroxyloxapine
Synonyms
8-hydroxyloxapine;8-Hydroxy Loxapine solution;Loxapine 8-Hydroxy Impurity;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol;2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol;Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
CBNumber
CB11370570
Molecular Formula
C18H18ClN3O2
Formula Weight
343.81
MOL File
61443-77-4.mol
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8-hydroxyloxapine Property

Melting point:
212-215°C
storage temp. 
Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility 
DMSO: soluble
form 
A solid
Stability:
Light Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21786
Product name
8-hydroxy Loxapine
Purity
≥98%
Packaging
500μg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
21786
Product name
8-hydroxy Loxapine
Purity
≥98%
Packaging
1mg
Price
$290
Updated
2024/03/01
TRC
Product number
H943730
Product name
8-HydroxyLoxapine
Packaging
1mg
Price
$260
Updated
2021/12/16
Usbiological
Product number
013929
Product name
8-Hydroxy Loxapine
Packaging
1mg
Price
$566
Updated
2021/12/16
AK Scientific
Product number
3064CA
Product name
8-Hydroxyloxapine
Packaging
1mg
Price
$421
Updated
2021/12/16
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8-hydroxyloxapine Chemical Properties,Usage,Production

Description

8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).

Chemical Properties

Pale Yellow Solid

Uses

The inactive

References

[1] MD P S, PH.D  Hubert H M V T Ph D  Roy Corbett Ph D. Atypical Neuroleptics Have Low Affinity for Dopamine D2 Receptors or Are Selective for D4 Receptors[J]. Neuropsychopharmacology, 1997, 16 2: 93-110. DOI: 10.1016/s0893-133x(96)00187-x
[2] YIN CHEONG WONG  Zhong Z  Siu Kwan Wo. Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC–MS/MS[J]. Journal of pharmaceutical and biomedical analysis, 2012, 58: Pages 83-93. DOI: 10.1016/j.jpba.2011.09.020
[3] ANDREW J GOUDIE. H1-histamine Receptor Affinity Predicts Short-term Weight Gain for Typical and Atypical Antipsychotic Drugs[J]. Neuropsychopharmacology, 2003, 28 12: 2209-2209. DOI: 10.1038/sj.npp.1300291
[4] JUSTIN FADEN L C. Examining the safety, efficacy, and patient acceptability of inhaled loxapine for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults[J]. Neuropsychiatric Disease and Treatment, 2019, 15 1: 2273-2283. DOI: 10.2147/ndt.s173567
[5] A. FULTON  G. D B  T Norman. Ligand binding and platelet uptake studies of loxapine, amoxapine and their 8-hydroxylated derivatives[J]. Journal of affective disorders, 1982, 4 2: Pages 113-119. DOI: 10.1016/0165-0327(82)90041-6

8-hydroxyloxapine Preparation Products And Raw materials

Raw materials

Preparation Products

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8-hydroxyloxapine Suppliers

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J & K SCIENTIFIC LTD.
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61443-77-4, 8-hydroxyloxapineRelated Search:

8-METHOXY LOXAPINE 2-METHOXY-BENZAMIDINE HCL 1-(3-CHLOROBENZYL)PIPERAZINE 1-(2-METHOXYBENZYL) PIPERAZINE 4-(4-Chlorophenoxy)phenol 8-hydroxyloxapine CHEMBRDG-BB 4022460 Dibenz-(b,f)-1,4-oxazephine Amoxapine 1-(2-PHENOXYPHENYL)METHANAMINE HYDROCHLORIDE 2-Hydroxy-benzamidine HCl loxapine

  • 8-hydroxyloxapine
  • 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol
  • 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol
  • Loxapine 8-Hydroxy Impurity
  • Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
  • 8-Hydroxy Loxapine solution
  • 61443-77-4
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals