4-(4-Chlorophenoxy)phenol
- Product Name
- 4-(4-Chlorophenoxy)phenol
- CAS No.
- 21567-18-0
- Chemical Name
- 4-(4-Chlorophenoxy)phenol
- Synonyms
- 4-(4-Chlorophenoxy);p-(p-Chlorophenoxy)phenol;4-(4-Chlorophenoxy)phenol;4-(4-Chlorophenyloxy)phenol;Phenol, 4-(4-chlorophenoxy)-;4-(4-CHLOROPHENOXY)PHENOL,99.5%;4-Hydroxy-4-chloro-diphenylether;4-Chloro-4'-hydroxydiphenyl ether;4-Chloro-4'-hydroxydiphenyl Ether >JR-7141, 4-(4-Chlorophenoxy)phenol, 97%
- CBNumber
- CB71095617
- Molecular Formula
- C12H9ClO2
- Formula Weight
- 220.65
- MOL File
- 21567-18-0.mol
4-(4-Chlorophenoxy)phenol Property
- Melting point:
- 80-85 °C
- Boiling point:
- 169°C/2.5mmHg(lit.)
- storage temp.
- 2-8°C
- form
- powder to crystal
- color
- White to Light yellow to Light orange
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-41-43
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HS Code
- 2909.50.5000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 695343
- Product name
- 4-(4-Chlorophenoxy)phenol
- Purity
- 97%
- Packaging
- 5g
- Price
- $176
- Updated
- 2023/06/20
- Product number
- 695343
- Product name
- 4-(4-Chlorophenoxy)phenol
- Purity
- 97%
- Packaging
- 25g
- Price
- $471
- Updated
- 2023/06/20
- Product number
- C2335
- Product name
- 4-Chloro-4'-hydroxydiphenyl Ether
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $87
- Updated
- 2021/12/16
- Product number
- C2335
- Product name
- 4-Chloro-4'-hydroxydiphenyl Ether
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $344
- Updated
- 2024/03/01
- Product number
- C596708
- Product name
- 4-(4-Chlorophenoxy)phenol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
4-(4-Chlorophenoxy)phenol Chemical Properties,Usage,Production
Chemical Properties
Light yellow solid
Synthesis
40843-46-7
21567-18-0
Step 2; 4-(4-Chlorophenoxy)phenol; Following the general procedure of Example 12 (Step 2), boron tribromide (1.0 M dichloromethane solution, 9.66 mL, 9.66 mmol) was added to a solution of dichloromethane (15 mL) of the product of Step 1 (0.76 g, 3.22 mmol), and the reaction was completed to give 4-(4-chlorophenoxy)phenol ( 0.37 g, 52%), the product was a light green solid. Step 2; 4-(4-Chlorophenoxy)phenol; To a solution of dichloromethane (50 mL) of the product of Step 1 (2.86 g, 12.18 mmol) was added boron tribromide (1.0 M solution in dichloromethane, 30 mL, 30.5 mmol) dropwise over 5 min at -78 °C. The reaction mixture was stirred at -78°C for 1 hour, then warmed to ambient temperature and continued stirring for 1 hour. Upon completion of the reaction, the mixture was cooled to 0 °C and slowly added to cold water/dichloromethane (50 mL/50 mL). The organic phase was washed sequentially with water and brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by rapid chromatography on silica gel using hexane/EtOAc (gradient elution) to afford 4-(4-chlorophenoxy)phenol (2 g, 75%); 1H NMR (400 MHz, CDCl3) δ 4.8 (s, 1H), 7.23-7.26 (m, 2H), 6.81-6.92 (m, 6H). Step 2; 4-(4-Chlorophenoxy)phenol; Boron tribromide (7.6 mL, 80.3 mmol) was added dropwise over 5 min at -78 °C to a solution of dichloromethane (72 mL) of the product of step 1 (6.3 g, 26.8 mmol). The reaction mixture was stirred at -78 °C for 1 hour, then warmed to ambient temperature and continued stirring for 1 hour. Upon completion of the reaction, the mixture was cooled to 0 °C and slowly added to cold water/dichloromethane. The organic phase was washed sequentially with water and brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by rapid chromatography on silica gel using EtOAc/hexane (gradient elution) to afford 4-(4-chlorophenoxy)phenol (4.50 g, 76%).
References
[1] Patent: US2007/66820, 2007, A1. Location in patent: Page/Page column 25; 27; 29
[2] Barell-Festschr. S. 266, 269, 272, 273,
[3] Organic Process Research and Development, 2009, vol. 13, # 6, p. 1177 - 1184
[4] Patent: WO2011/11598, 2011, A1. Location in patent: Page/Page column 16
[5] Chem.Abstr., 1976, vol. 85, # 20843,
4-(4-Chlorophenoxy)phenol Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-(4-Chlorophenoxy)phenol manufacturers
- Product
- 4-(4-chlorophenoxy)phenol 21567-18-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-02-03