4A3-SC8 Chemical Properties

Boiling point:

1127.383±65.00 °C(Press: 760.00 Torr)(predicted)

Density 

1.068±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

solubility 

Chloroform: Soluble
Ethanol: Soluble

form 

Liquid

pka

9.329±0.50(predicted)

color 

Colorless to light yellow

InChIKey

HMIDEMNFLBUNTB-UHFFFAOYSA-N

SMILES

N(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCCN(C)CCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC

4A3-SC8 Usage And Synthesis

Uses

4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model[1].

in vivo

References

[1] Zhou K, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):520-5. DOI:10.1073/pnas.1520756113
[2] ÁLVAREZ-BENEDICTO E, FARBIAK L, RAMÍREZ M M, et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)†[J]. Biomaterials Science, 2021, 2: 549-559. DOI: 10.1039/d1bm01454d
[3] LUKAS FARBIAK. All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo[J]. Advanced Materials, 2021, 33 30. DOI: 10.1002/adma.202006619
[4] HU XIONG . Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo[J]. Journal of Controlled Release, 2020, 325: Pages 198-205. DOI: 10.1016/j.jconrel.2020.06.030