vanoxonin
vanoxonin Basic information
- Product Name:
- vanoxonin
- Synonyms:
-
- vanoxonin
- (+)-N-(2,3-Dihydroxybenzoyl)-L-Thr-N5-Ac-N5-hydroxy-L-Orn-OH
- Antibitic MG-245CF2A
- N5-Acetyl-N2-[N-(2,3-dihydroxybenzoyl)-L-threonyl]-N5-hydroxy-L-ornithine
- Antibiotic MG 245CF2A
- MG-245-CF2-A
- N-(2,3-dihydroxybenzoyl)-L-threonyl-N5-acetyl-N5-hydroxy-L-ornithine
- CAS:
- 86933-99-5
- MF:
- C18H25N3O9
- MW:
- 427.408
- Mol File:
- 86933-99-5.mol
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vanoxonin Chemical Properties
- storage temp.
- -20°C
- form
- A solid
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vanoxonin Usage And Synthesis
Biological Activity
Vanoxonin is a bacterial metabolite that has been found in S. hirsuta.1 It forms a complex with vanadium, and the complex inhibits thymidylate synthetase with an IC50 value of 0.7 μg/ml. The vanoxonin-vanadium complex is cytotoxic to L1210 leukemia cells (MIC = 25 μg/ml) and increases survival in Ehrlich murine spontaneous adenocarcinoma and L1210 mouse tumor models.
References
1.Kanai, F., Sawa, T., Hamada, M., et al.Vanoxonin, a new inhibitor of thymidylate synthetaseJ. Antibiot. (Tokyo)36(6)656-660(1983)
vanoxoninSupplier
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