TNP 351
TNP 351 Basic information
- Product Name:
- TNP 351
- Synonyms:
-
- TNP 351
- N-[4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid
- L-Glutamic acid, N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-
- CAS:
- 125991-51-7
- MF:
- C21H24N6O5
- MW:
- 440.45
- Mol File:
- 125991-51-7.mol
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TNP 351 Usage And Synthesis
Uses
TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1].
References
[1] F Itoh ,et al. Novel pyrrolo[2,3-d]pyrimidine Antifolate TNP-351: Cytotoxic Effect on Methotrexate-Resistant CCRF-CEM Cells and Inhibition of Transformylases of De Novo Purine Biosynthesis. Cancer Chemother Pharmacol. 1994;34(4):273-9. DOI:10.1007/BF00686032
TNP 351Supplier
Beijing Jin Ming Biotechnology Co., Ltd.
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- 010-60605840 18892239720
- psaitong@jm-bio.com
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
HANGZHOU CLAP TECHNOLOGY CO.,LTD
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- 86-571-88216897,88216896 13588875226
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Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
TargetMol Chemicals Inc.
- Tel
- 4008200310
- marketing@tsbiochem.com