Basic information Safety Supplier Related

L-AP4

Basic information Safety Supplier Related

L-AP4 Basic information

Product Name:
L-AP4
Synonyms:
  • L-AP4
  • L(+)-2-AMINO-4-PHOSPHONOBUTANOIC ACID
  • L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID
  • L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID (L-AP4)
  • L(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID 97%
  • (2S)-2-Amino-4-phosphonobutyric acid
  • (S)-4-Phosphono-2-aminobutanoic acid
  • (S)-4-Phosphono-2-aminobutyric acid
CAS:
23052-81-5
MF:
C4H10NO5P
MW:
183.1
EINECS:
200-258-5
Product Categories:
  • Glutamate receptor
  • Glutamate
Mol File:
23052-81-5.mol
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L-AP4 Chemical Properties

Melting point:
207-215 °C
Boiling point:
491.7±55.0 °C(Predicted)
Density 
1.628±0.06 g/cm3(Predicted)
storage temp. 
0-6°C
pka
2.19±0.10(Predicted)
form 
solid
Water Solubility 
Soluble to 5 mM in water and to 100 mM in 1eq. NaOH
Sensitive 
Light Sensitive
CAS DataBase Reference
23052-81-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
ES7191700

MSDS

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L-AP4 Usage And Synthesis

Chemical Properties

white to off-white crystalline powder

Uses

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.

Biological Activity

Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Also available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

L-AP4Supplier

J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801
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3bsc@sina.com
Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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Ascent Scientific
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4401179829988
Email
customerservice@ascentscientific.co.uk
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Email
sales@sinch.com.cn