1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Basic information
- Product Name:
- 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
- Synonyms:
-
- 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
- 1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanonehydrochloride
- 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one hydrochloride
- Antitrypanosomal agent 1
- 1-Propanone1-(34-dichlorophenyl)-3-(dimethylamino)-hydrochloride
- 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one
- Antitrypanosomal agent-1,Antitrypanosomal agent 1,T.brucei,trypanothione,inhibit,glutathione,Antitrypanosomal agent1,Inhibitor,reductase,Parasite,anti-trypanosomal
- CAS:
- 75144-12-6
- MF:
- C11H14Cl3NO
- MW:
- 282.59
- Mol File:
- 75144-12-6.mol
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1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Chemical Properties
- Melting point:
- 186 - 188°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White
- Water Solubility
- Water: 10 mg/mL (35.39 mM)
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1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Usage And Synthesis
Biological Activity
Antitrypanosomal agent 1 is a potent and selective inhibitor of trypanothione reductase with IC50 of 3.3 μM. It inhibits glutathione reductase with IC50 of 64.8 μM; inhibits Trypanosoma brucei with EC50 of 1 μM. It has antitrypanosomal activity.
in vitro
Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20.
target
IC50: 3.3 μM (trypanothione reductase) and 64.8 μM (glutathione reductase)
EC50: 1 μM ( T. brucei )
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