1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Chemical Properties

Melting point:

186 - 188°C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

Off-White

Water Solubility 

Water: 10 mg/mL (35.39 mM)

1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Usage And Synthesis

Uses

Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1].

Biological Activity

Antitrypanosomal agent 1 is a potent and selective inhibitor of trypanothione reductase with IC50 of 3.3 μM. It inhibits glutathione reductase with IC50 of 64.8 μM; inhibits Trypanosoma brucei with EC50 of 1 μM. It has antitrypanosomal activity.

in vitro

target

References

[1] Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3. DOI:10.1016/j.bmcl.2006.12.016

1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL(75144-12-6)Related Product Information

• 1-(4-CHLOROPHENYL)-3-(DIMETHYLAMINO)PROPAN-1-ONE HYDROCHLORIDE
• 3',4'-DICHLOROPROPIOPHENONE
• 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL