4,4'-DICHLOROBUTYROPHENONE Chemical Properties

Melting point:

29-30 °C

Boiling point:

153-155 °C(Press: 2 Torr)

Density 

1.2372 (estimate)

refractive index 

1.5600

form 

Pellets

color 

White

BRN 

879782

CAS DataBase Reference

40877-09-6(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

24/25

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

4,4'-DICHLOROBUTYROPHENONE Usage And Synthesis

Chemical Properties

clear yellow to brown liquid after melting

Synthesis

To a dry reaction tube were sequentially added 0.2 mmol 1-(4-chlorophenyl)cyclobutanol, 0.02 mmol manganese dichloride (MnCl2), 0.6 mmol trimethylsilyl chloride (TMSCl), 0.4 mmol 2-iodobenzoic acid and 1 mL acetonitrile (MeCN). The reaction mixture was stirred at 50°C for 7 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by column chromatography using a solvent mixture of petroleum ether and ethyl acetate as eluent (20:1 v/v). The final product was 4,4'-dichlorobutyrophenone in 88.2% yield and 98% purity.

References

[1] Organic Letters, 2016, vol. 18, # 4, p. 684 - 687
[2] Patent: CN106008181, 2016, A. Location in patent: Paragraph 0039-0041

4,4'-DICHLOROBUTYROPHENONE(40877-09-6)Related Product Information

• 3,4-Dichlorobutyrophenone
• 2,2-DICHLOROBUTYROPHENONE,ALPHA,ALPHA-DICHLOROBUTYROPHENONE
• α,α-Dichlorobutyrophenone
• 2-bromo-4,4'-dichlorobutyrophenone
• Γ,P-DICHLOROBUTYROPHENONE
• a,p-DICHLOROBUTYROPHENONE,2',4'-DICHLOROBUTYROPHENONE
• 3,4-DICHLOROBUTYROPHENONE
• 3,4,4,4-TETRACHLORO-1-(4-CHLOROPHENYL)BUTAN-1-ONE
• 4-CHLORO-1-(3,4-DICHLOROPHENYL)-1-OXOBUTANE
• 4,4,4-TRICHLORO-1-(4-CHLOROPHENYL)-3-HYDROXYBUTAN-1-ONE
• 4,4'-DICHLOROBUTYROPHENONE
• (2,4-DICHLOROPHENYL)[3-(TRICHLOROMETHYL)OXIRAN-2-YL]METHANONE