3-(BENZYLAMINO)PROPIONITRILE Chemical Properties

Melting point:

70 °C

Boiling point:

276.13°C (rough estimate)

Density 

1.024 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.5308(lit.)

Flash point:

>230 °F

storage temp. 

Refrigerator

solubility 

Soluble in DMSO.

form 

Liquid

pka

7.29±0.19(Predicted)

color 

Clear Colorless

Specific Gravity

1.024

CAS DataBase Reference

706-03-6

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-37/39

RIDADR 

UN3276

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269095

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-(BENZYLAMINO)PROPIONITRILE Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

3-(Benzylamino)propionitrile was used as starting reagent in the synthesis of:

• (3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid, key chiral building block for synthesis of biologically active compounds
• 1-{[benzyl-(2-cyano-ethyl)-amino]-methyl}-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester
• 3-[benzyl-(3,5-dimethyl-pyrazol-1-ylmethyl)-amino]-propionitrile

Uses

3-(BenzylaMino)propionitrile is used in the michael addition of primary and secondary amines to acrylonitrile catalyzed by lipases.

Application

3-(Benzylamino)propionitrile was used as starting reagent in the synthesis of:
(3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid, key chiral building block for synthesis of biologically active compounds
1-{[benzyl-(2-cyano-ethyl)-amino]-methyl}-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester
3-[benzyl-(3,5-dimethyl-pyrazol-1-ylmethyl)-amino]-propionitrile

General Description

3-(Benzylamino)propionitrile undergoes aza-type Michael reaction with 1-hydroxymethyl-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester under mild conditions.

3-(BENZYLAMINO)PROPIONITRILE(706-03-6)Related Product Information

• 3-(BENZYLAMINO)PROPIONITRILE
• 1,3-DIBENZYL-5-CYANOHEXAHYDROPYRIMIDINE
• 1-Benzhydrylazetane-3-carbonitrile
• 3-(4-CHLORO-BENZYLAMINO)-PROPIONITRILE
• Propionitrile
• 6-(4-FLUOROPHENYL)-1,2-DIHYDRO-2-OXOPYRIDINE-3-CARBONITRILE
• N-(2-CYANOETHYL)-PHTHALIMIDE
• 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 6-(4-CHLOROPHENYL)-1-(3,4-DICHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 4-(METHYLTHIO)-6-OXO-2-PHENYL-1,6-DIHYDROPYRIMIDINE-5-CARBONITRILE
• 1-(3-CHLOROBENZYL)-2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 1-(3,4-DICHLOROBENZYL)-6-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 1-[[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](METHYL)AMINO]-3-(4-FLUOROBENZYL)-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBONITRILE
• N1,N1-DI(2-CYANOETHYL)-4-CHLORO-3-NITROBENZAMIDE
• 6-(4-FLUOROPHENYL)-2-OXO-1-[3-(TRIFLUOROMETHYL)BENZYL]-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 1-(2-CHLOROBENZYL)-2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 1-(4-CHLOROBENZYL)-6-(DIMETHOXYMETHYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 1-METHYL-4-(METHYLSULFANYL)-2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE