1,3-dibromo-5-tert-butylbenzene Chemical Properties

Boiling point:

250.0±20.0 °C(Predicted)

Density 

1.549±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

Pale Brown

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2903998090

1,3-dibromo-5-tert-butylbenzene Usage And Synthesis

Uses

1,3-dibromo-5-tert-butylbenzene is a versatile building block that can be used to create a range of compounds.

Application

To a stirring solution of 1,3-dibromo-5-tert-butylbenzene (5.0 g, 17.0 mmol) in dry ether at ?78°C, n-Butyllithium (1.1 equiv.) was added dropwise. After stirring for 30 min under the N2 atmosphere, N-methoxy-N-methylacetamide (2.4 ml, 22.1 mmol) was added dropwise. The reaction mixture was allowed to warm to room temperature and stirred for 12 h. After quenching with a saturated solution of ammonium chloride, water was added, and the mixture was extracted with ether (2 × 150 ml). The combined organic extracts were washed with water (2 × 200 ml), dried with MgSO4 and evaporated to give a crude product. Purification was done by silica gel flash column chromatography using ethyl acetate: n-hexane mixture (v:v = 1:28) as eluent to give 1-(3-bromo-5-(tert-butyl)phenyl)ethanone as pale yellow oil.

1,3-dibromo-5-tert-butylbenzene(129316-09-2)Related Product Information

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