2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE
2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE Basic information
- Product Name:
- 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE
- Synonyms:
-
- PRONETHALOL HYDROCHLORIDE
- 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE
- PronethalolHCl
- 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol hydrochloride
- alderlinhydrochloride
- alpha-(((1-methylethyl)amino)methyl)-2-naphthalenemethanol,hydrochloride
- alpha-((isopropylamino)methyl)-2-naphthalenemethanolhydrochloride
- alpha-((isopropylamino)methyl)-naphthalenemethanohydrochloride
- CAS:
- 51-02-5
- MF:
- C15H20ClNO
- MW:
- 265.78
- Mol File:
- 51-02-5.mol
2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE Chemical Properties
- Melting point:
- 184°
- storage temp.
- Store at RT
- form
- Powder
- Water Solubility
- Soluble to 100 mM in water
- IARC
- 3 (Vol. 13, Sup 7) 1987
- EPA Substance Registry System
- Pronetalol hydrochloride (51-02-5)
2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE Usage And Synthesis
Uses
Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].
Definition
ChEBI: Pronetalol hydrochloride is an organic molecular entity.
Biological Activity
β -adrenergic antagonist, clinically effective in the treatment of angina pectoris and some arrhythmias.
in vivo
Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp–/– mice[2].
IC 50
β adrenergic receptor
References
[1] Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-8. DOI:10.1016/0002-8703(66)90217-1
[2] Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129(8):3121-3133. DOI:10.1172/JCI125965
[3] Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-508.
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