THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID Chemical Properties

Melting point:

293 °C

Boiling point:

397.4±22.0 °C(Predicted)

Density 

1.508±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

form 

solid

pka

2.33±0.30(Predicted)

color 

Off-white

InChI

InChI=1S/C8H5NO2S/c10-8(11)6-4-5-2-1-3-9-7(5)12-6/h1-4H,(H,10,11)

InChIKey

XGCSHAYMNOFFNA-UHFFFAOYSA-N

SMILES

C12SC(C(O)=O)=CC1=CC=CN=2

CAS DataBase Reference

59944-76-2

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2934999090

THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID Usage And Synthesis

Uses

Thieno[2,3-b]pyridine-2-carboxylic Acid is a useful reagent in study of neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for treatment of Alzheimer’s disease.

Definition

ChEBI: Thieno[2,3-b]pyridine-2-carboxylic acid is a thienopyridine.

Synthesis

Methyl thieno[2,3-b]pyridine-2-carboxylate (C101, 0.700 g, 3.63 mmol) was used as a raw material and dissolved in a solvent mixture of methanol (15 mL) and water (3 mL). At room temperature, 2N sodium hydroxide solution (1.82 mL, 3.63 mmol) was added dropwise and the reaction mixture was stirred for 24 hours. Upon completion of the reaction, the mixture was concentrated under vacuum to remove most of the solvent. Subsequently, water (40 mL) was added to dissolve the residue. The resulting solution was acidified to pH 4 with concentrated hydrochloric acid, at which point thieno[2,3-b]pyridine-2-carboxylic acid (C102) precipitated as a white precipitate. The precipitate was collected by filtration to give the target product in 85% yield. The product was analyzed by mass spectrometry (EI) and showed a molecular ion peak m/z of 179 (M+), which is consistent with the theoretical value of the molecular formula C8H5NO2S.

References

[1] Patent: US2003/153595, 2003, A1
[2] Patent: US2003/45540, 2003, A1
[3] Patent: US2012/190674, 2012, A1. Location in patent: Page/Page column 91

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