ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > MK-0812
MK-0812
MK-0812 Basic information
- Product Name:
- MK-0812
- Synonyms:
-
- MK-0812
- 1,5-Anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]am
- [(1S,3R)-3-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
- CS-206
- D-erythro-Pentitol, 1,5-anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-
- MK0812,MK-0812
- MK0812(BASE)
- 1,5-Anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-D-erythro-pentitol
- CAS:
- 624733-88-6
- MF:
- C24H34F3N3O3
- MW:
- 469.54
- Mol File:
- 624733-88-6.mol
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MK-0812 Chemical Properties
- Boiling point:
- 562.0±50.0 °C(Predicted)
- Density
- 1.24
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 8.51±0.40(Predicted)
- color
- White to off-white
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MK-0812 Usage And Synthesis
Uses
MK-0812 is a potent C-C chemokine receptor type 2 (CCR2) antagonist.
in vivo
MK-0812 is administered by continuous i.v. infusion to maintain a constant level of the drug in blood[1]. Administration of MK0812 at 30 mg/kg, p.o. reduces the frequency of Ly6G-Ly6Chi monocytes in the peripheral blood, while no impact on circulating Ly6G+Ly6C+ neutrophil frequency is observed. In addition, MK0812 treatment causes a dose-dependent reduction in circulating Ly6Chi monocytes and a corresponding elevation in the CCR2 ligand CCL2[2].
IC 50
CCR2
MK-0812Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Chembest Research Laboratories Limited
- Tel
- +86-21-20908456
- sales@BioChemBest.com
Beijing HuaMeiHuLiBiological Chemical
- Tel
- 010-56205725
- waley188@sohu.com
NCE Biomedical Co.,Ltd.
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
ExcelChemical (Shanghai) Chemical Technology Co., Ltd.
- Tel
- +86 13671938079