4-Bromoindole-2-carboxylic acid methyl ester Chemical Properties

Boiling point:

386.2±22.0 °C(Predicted)

Density 

1.629±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

14.04±0.30(Predicted)

form 

solid

color 

Beige

Safety Information

HazardClass 

IRRITANT

HS Code 

2924297099

4-Bromoindole-2-carboxylic acid methyl ester Usage And Synthesis

Synthesis

GENERAL METHOD: Methyl 3-aryl-2-azidoacrylate (20.0 mmol) was added in a single addition to a pre-heated to reflux xylene solution (75 mL) and the reaction was kept at reflux for 2 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator. The resulting residue was purified by silica gel column chromatography with mixed petroleum ether/ethyl acetate solvent as eluent. The synthesis of compounds 12, 18 and 19 has been reported in the literature [9b, 13, 14].

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 49, p. 379 - 396

4-Bromoindole-2-carboxylic acid methyl ester(167479-13-2)Related Product Information

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