LATHOSTEROL Chemical Properties

Melting point:

126°C

Boiling point:

452.8°C (rough estimate)

Density 

0.9610 (rough estimate)

refractive index 

1.5250 (estimate)

storage temp. 

-20°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Sonicated)

form 

Solid

pka

15.10±0.70(Predicted)

color 

White to Off-White

InChI

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3

InChIKey

IZVFFXVYBHFIHY-UHFFFAOYSA-N

SMILES

OC1CC2C(C3CCC4(C(CCC4C(CCCC(C)C)C)C3=CC2)C)(CC1)C

Safety Information

WGK Germany 

3

RTECS 

FZ7000000

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

LATHOSTEROL Usage And Synthesis

Uses

A Cholesterol (C432501) metabolite. Lathosterol (indicating cholesterol synthesis) and Sitosterol (indicating cholesterol absorption) also decreased with deteriorating health. Low Lathosterol, Sitosterol (S497050), and Cholesterol (C432501) predicted mortality additively and independently of each other.

Uses

Lathosterol has been used as a standard for the estimation of the concentrations of cholesterol and plant sterols.

Uses

5α-Cholest-7-en-3β-ol was used as a substrate in enzymatic assay for plasma cholesterol. It was used to supplement diet of Daphnia galeata to study the effect on life-history traits.

Definition

ChEBI: A cholestanoid that is (5alpha)-cholest-7-ene substituted by a beta-hydroxy group at position 3.

General Description

Lathosterol is a cholesterol synthesis precursor.

Biochem/physiol Actions

5α-Cholest-7-en-3β-ol (Lathosterol) is an intermediate in cholesterol biosynthesis pathway. Lathosterol in serum is carried on lipoproteins and is indicative of the rate of cholesterol synthesis. It acts as a marker of synthesis of cholesterol and is not affected by dietary consumption of cholesterol.

IC 50

Human Endogenous Metabolite

LATHOSTEROL(80-99-9)Related Product Information

• Lathosterol-1,2,5alpha,6alpha-D4
• lathosterol delta-5-dehydrogenase
• Lathosterol TMS
• (Lathosterol-1,2,5α,6α-D4)
• 7,5ALPHA-CHOLESTEN-4ALPHA-METHYL-3BETA-OL
• 5ALPHA-CHOLEST-7-EN-3BETA-OL-1,2,5,6-D4
• 7,5ALPHA-CHOLESTEN-4ALPHA-METHYL-3BETA-OL 3-ACETATE
• 5-alpha-ergost-7-en-3-beta-ol
• AGOSTEROL A
• LATHOSTEROL