(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Basic information
- Product Name:
- (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
- Synonyms:
-
- (OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
- VO-OHpic trihydrate
- VO Ohpic
- VO-Ohpic
- VO-OHpic (PTEN Inhibitor)
- VO-OHpic (hydrate)
- (OC-6-45)-aqua(3-Hydroxy-2-pyridinecarboxylato-kappaN1,kappaO2)[3-(hydroxy-kappaO)-2-pyridinecarboxylato(2-)-kappaO2]oxovanadate(1-) hydrogen trihydrate
- VO-OHpic trihydrate >=98% (HPLC), solid
- CAS:
- 476310-60-8
- MF:
- C12H8N2O7V.3H2O
- MW:
- 397.189
- Mol File:
- 476310-60-8.mol
(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Chemical Properties
- storage temp.
- -20°C
- solubility
- DMSO: >10mg/mL
- form
- solid
- color
- gray
- InChI
- InChI=1S/2C6H5NO3.3H2O.O.V.H/c2*8-4-2-1-3-7-5(4)6(9)10;;;;;;/h2*1-3,8H,(H,9,10);3*1H2;;;/q;;;;;;+3;/p-3
- InChIKey
- XSVSRTSHXJGGKW-UHFFFAOYSA-K
- SMILES
- O.O.C1=CN=C2C(=O)O[V]([H])(=O)(OC(=O)C3C(O)=CC=CN=3)OC2=C1.O
(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate Usage And Synthesis
Uses
VO-?OHPIC Trihydrate is used to inactivate tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (Pten) which induces a respons that opposes tumorigeneis.
Uses
VO-OHpic trihydrate has been used in studying the role of phosphatase and tensin homolog (PTEN) in polycomb repressive complex 2 (PRC2)-mediated apoptosis. It also has been used as a PTEN inhibitor to study the neuroprotective effect of melatonin in amyloid beta (Aβ)-induced neurotoxicity via PTEN pathway.
General Description
VO-OHpic is a vanadium complex. VO-OHpic might act as a possible pro-senescence anti-cancer drug for treating cancers with reduced phosphatase and tensin homolog (PTEN) expression. It blocks cell viability, cell proliferation, colony formation and induced senescence-associated β-galactosidase activity in Hep3B cells.
Biochem/physiol Actions
VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor.
in vivo
PTEN is inhibited in mice by intra-peritoneal injection of VO-OHpic (10 μg/kg) 30 min before ischemia and then exposed them to 30 min of ischemia and 120 min of reperfusion. At the end of the experiment, myocardial infarct size is measured by triphenyltetrazolium chloride (TTC). Myocardial infarct size is significantly decreased in VO-treated mice (25±6 vs. 56±5 %, n=7, P<0.01). There is no difference in the area at risk between these two groups (46±3 vs. 57±3 %, n=7, P>0.05)[3].
(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrateSupplier
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