4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride Chemical Properties

Melting point:

>75°C (dec.)

storage temp. 

2-8°C

solubility 

DMSO: >20mg/mL

form 

powder

color 

white to off-white

Stability:

Hygroscopic

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

WGK Germany 

3

4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride Usage And Synthesis

Uses

Desvenlafaxine Hydrochloride is a major active metabolite of venlafaxine (V120000), which is a slective serotonin noradrenaline reuptake inhibitor and used as an antidepressant.

Uses

Desvenlafaxine hydrochloride has been used to evaluate if its occurrence in drinking water at environmental concentrations could induce neuronal gene expression.

Biochem/physiol Actions

Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM.

4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride(300827-87-6)Related Product Information

• 1-[2-(DiMethyloxidoaMino)-1-(4-Methoxyphenyl)ethyl]cyclohexanol
• rac N-DesMethyl-N-(4-Methoxyphenethyl) Venlafaxine
• 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile
• 1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol hydrochloride
• ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate hydrochloride
• Venlafaxine N-Dimer
• (5RS)-5-(4-Methoxyphenyl)-3-Methyl-1-oxa-3-azaspiro-[5.5]undecane Hydrochloride
• Venlafaxine Related Compound A (10 mg) (1-(1-(4-Methoxyphenyl)-2-(methylamino)ethyl)cyclohexanol hydrochloride)
• D,L-N,N-Didesmethyl-N-(4-methoxyphenethyl) Venlafaxine
• (2RS)-2-(Cyclohex-1-enyl)-2-(4-Methoxyphenyl)-N,N-diMethylethanaMine Hydrochloride
• (2RS)-2-Cyclohexyl-2-(4-Methoxyphenyl)-N,NdiMethylethanaMineHydrochloride
• Venlafaxine hydrochloride