(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Chemical Properties

Boiling point:

595.6±50.0 °C(Predicted)

Density 

1.10±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

pka

14.67±0.29(Predicted)

color 

White to off-white

InChIKey

JLYBBRAAICDTIS-AYEHCKLZSA-N

CAS DataBase Reference

88930-15-8

Safety Information

HS Code 

2934999090

(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Usage And Synthesis

Appearance

Constit. of Cucurbita foeridissimia (buffalo gourd).Amorph. powder.

Chemical Properties

Off-white powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Momordica grosvenori.

Uses

Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

Definition

ChEBI: Mogrol is a tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii. It has a role as an antineoplastic agent. It is a tetracyclic triterpenoid and a hydroxy seco-steroid. It is functionally related to a cucurbitadienol.

Biochem/physiol Actions

Mogrol is an aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities. It induces apoptosis in K562 leukemia cells through suppression of ERK1/2 and STAT3 pathways. Mogrol appears to ameliorate the memory impairment caused by Aβ1-42 in mice. Mogrol increases AMPK activity in hepatocytes and suppresses adipocyte differentiation in 3T3-L1 cells.

IC 50

ERK1; ERK2; STAT3

References

[1] Liu C, et al. Mogrol represents a novel leukemia therapeutic, via ERK and STAT3 inhibition. Am J Cancer Res. 2015 Mar 15;5(4):1308-18.
[2] Naoki Harada, et al. Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation. PLoS One. 2

(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol(88930-15-8)Related Product Information

• Crotonic acid
• Mogroside III A2
• Neomogroside
• MOGROSIDE III
• Mogroside ⅢA1
• Mogroside II B
• Mogroside I A1
• mogroside IV
• Mogroside II A1
• MogrosideIIE
• Siamenoside I
• Mogroside IVa
• Mogroside Ⅲe
• 11-Oxomogroside I
• Mogroside V
• MOGROSIDE IV
• isoMogroside V
• Mogroside I E1