(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Chemical Properties

Boiling point:

595.6±50.0 °C(Predicted)

Density 

1.10±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

14.67±0.29(Predicted)

CAS DataBase Reference

88930-15-8

Safety Information

HS Code 

2934999090

(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Usage And Synthesis

Appearance

Constit. of Cucurbita foeridissimia (buffalo gourd).Amorph. powder.

Definition

ChEBI: Mogrol is a tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii. It has a role as an antineoplastic agent. It is a tetracyclic triterpenoid and a hydroxy seco-steroid. It is functionally related to a cucurbitadienol.

Biochem/physiol Actions

Mogrol is an aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities. It induces apoptosis in K562 leukemia cells through suppression of ERK1/2 and STAT3 pathways. Mogrol appears to ameliorate the memory impairment caused by Aβ1-42 in mice. Mogrol increases AMPK activity in hepatocytes and suppresses adipocyte differentiation in 3T3-L1 cells.

(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol(88930-15-8)Related Product Information

• Mogroside III A2
• Neomogroside
• MOGROSIDE III
• Mogroside ⅢA1
• Mogroside II B
• Mogroside I A1
• mogroside IV
• Mogroside II A1
• MogrosideIIE
• Siamenoside I
• Mogroside IVa
• Mogroside Ⅲe
• 11-Oxomogroside I
• Mogroside V
• MOGROSIDE IV
• isoMogroside V
• Mogroside I E1
• Crotonic acid