(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol
Appearance- Product Name
- (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol
- CAS No.
- 88930-15-8
- Chemical Name
- (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol
- Synonyms
- Mogrol;Mogrol-RM;Mogrol, >98%;Monascus alcohol;Mogrol, 10 mM in DMSO;(24R)-Cucurbit-5-ene-3β,11α,24,25-tetrol;(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol;(10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene;ERK,inhibit,Extracellular signal regulated kinases,STAT,Mogrol,Inhibitor;(3S,8S,9R,10R,11R,13R,14S,17R)-17-((2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl)-4,4,9,13,14-pentamethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,11-diol
- CBNumber
- CB12165711
- Molecular Formula
- C30H52O4
- Formula Weight
- 476.73
- MOL File
- 88930-15-8.mol
(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Property
- Boiling point:
- 595.6±50.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 14.67±0.29(Predicted)
- color
- White to off-white
- InChIKey
- JLYBBRAAICDTIS-AYEHCKLZSA-N
- CAS DataBase Reference
- 88930-15-8
Safety
- HS Code
- 2934999090
N-Bromosuccinimide Price
- Product number
- PHL84241
- Product name
- Mogrol
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $555
- Updated
- 2025/07/31
- Product number
- CS-6010
- Product name
- Mogrol
- Purity
- 98.06%
- Packaging
- 25mg
- Price
- $640
- Updated
- 2021/12/16
- Product number
- CS-6010
- Product name
- Mogrol
- Purity
- 98.06%
- Packaging
- 5mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- CS-6010
- Product name
- Mogrol
- Purity
- 98.06%
- Packaging
- 1mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-6010
- Product name
- Mogrol
- Purity
- 98.06%
- Packaging
- 10mg
- Price
- $320
- Updated
- 2021/12/16
(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Chemical Properties,Usage,Production
Appearance
Constit. of Cucurbita foeridissimia (buffalo gourd).Amorph. powder.
Chemical Properties
Off-white powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Momordica grosvenori.
Uses
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
Definition
ChEBI: Mogrol is a tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii. It has a role as an antineoplastic agent. It is a tetracyclic triterpenoid and a hydroxy seco-steroid. It is functionally related to a cucurbitadienol.
Biochem/physiol Actions
Mogrol is an aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities. It induces apoptosis in K562 leukemia cells through suppression of ERK1/2 and STAT3 pathways. Mogrol appears to ameliorate the memory impairment caused by Aβ1-42 in mice. Mogrol increases AMPK activity in hepatocytes and suppresses adipocyte differentiation in 3T3-L1 cells.
IC 50
ERK1; ERK2; STAT3
References
[1] Liu C, et al. Mogrol represents a novel leukemia therapeutic, via ERK and STAT3 inhibition. Am J Cancer Res. 2015 Mar 15;5(4):1308-18.
[2] Naoki Harada, et al. Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation. PLoS One. 2
(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol manufacturers
- Product
- Mogrol 88930-15-8
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-05-25