N-Methylleukotriene C4 Chemical Properties

Boiling point:

965.7±65.0 °C(Predicted)

Density 

1.202±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; Ethanol:H20 (95:5): 2 mg/ml; PBS (pH 7.2): 100 μg/ml

pka

2.23±0.10(Predicted)

N-Methylleukotriene C4 Usage And Synthesis

Uses

Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.

Uses

N-methyl Leukotriene C4 is synthetic analog of LTC4 with decreased binding affinity.

N-Methylleukotriene C4(131391-65-6)Related Product Information

• S-PROPYLGLUTATHIONE
• N-Methylleukotriene C4
• 11-TRANS LEUKOTRIENE D4
• 11-TRANS LEUKOTRIENE C4
• S-ETHYLGLUTATHIONE
• S-BUTYLGLUTATHIONE
• S-PENTYLGLUTATHIONE
• S-HEXYLGLUTATHIONE