16-DOXYL-STEARIC ACID Chemical Properties

Melting point:

47-55 °C(lit.)

Flash point:

113 °C

storage temp. 

2-8°C

solubility 

DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml

form 

powder to crystal

color 

White to Yellow

Stability:

Hygroscopic

CAS DataBase Reference

53034-38-1

Safety Information

WGK Germany 

3

16-DOXYL-STEARIC ACID Usage And Synthesis

Description

16-doxyl Stearic acid is a form of stearic acid that contains a 4,4-dimethyl-3-oxazolinyloxy (DOXYL) group, creating a hydrophobic spin label. It is commonly used to study molecular aspects of membranes and hydrophobic proteins.

Uses

Involved in membrane studies including:

• Dynamics and state of lipid bilayer-internal water using 1H dynamic nuclear polarization
• Distribution of fatty acids
• Transversal relaxation of nitroxides for PELDOR Spectroscopy
• Effects of different lipid components on detergent-resistant membranes

Uses

16-DOXYL-stearic acid, free radical is a spin label for membrane fluidity studies. It can be used to study the dynamics of the lipid bilayer, distribution of fatty acids, and effects of lipid components on detergent-resistant membranes. It can be used for the investigation of surfactant effects on protein formulations by EPR spectroscopic technique.

Definition

ChEBI: 16-DOXYL-stearic acid is a member of aminoxyls. It is functionally related to a 4,4-dimethyloxazolidine-N-oxyl and an octadecanoic acid.

References

[1] NATALYA G KORMOSH. Conformational changes in inter-α-trypsin inhibitor heavy chain 4 activate its tumor-specific activity in mice with B16 melanoma.[J]. Molecular medicine reports, 2015: 4483-4493. DOI: 10.3892/mmr.2015.3961
[2] KARINE LAULAGNIER. Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization.[J]. Biochemical Journal, 2004, 380 Pt 1: 161-171. DOI: 10.1042/bj20031594
[3] EKATERINA A. VISHNYAKOVA . Spin-labeling study of membranes in wheat embryo axes. 1. Partitioning of doxyl stearates into the lipid domains[J]. Biochimica et biophysica acta. Biomembranes, 2000, 1467 2: Pages 380-394. DOI: 10.1016/s0005-2736(00)00234-0

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