SCHRADAN Chemical Properties

Melting point:

17℃

Boiling point:

bp0.5 120-125°; bp2.0 154°

Density 

1.24 g/cm³ (25 ºC)

refractive index 

1.4698 (589.3 nm 20℃)

form 

liquid

pka

0.85±0.70(Predicted)

color 

Viscous liquid

CAS DataBase Reference

152-16-9

EPA Substance Registry System

Schradan (152-16-9)

Safety Information

Hazard Codes 

T+

Risk Statements 

27/28

Safety Statements 

36/37-38-45

RIDADR 

3018

HazardClass 

6.1(a)

PackingGroup 

I

HS Code 

29299090

Hazardous Substances Data

152-16-9(Hazardous Substances Data)

Toxicity

LD50 in male, female rats (mg/kg): 9.1, 42 orally; 15, 44 dermally (Gaines)

SCHRADAN Usage And Synthesis

Description

OMPA is a dark brown viscous liquid.Molecular weight = 286.30; Boiling point = 120-125℃ at0.5 mmHg; Freezing/Melting point =14-20℃. HazardIdentification (based on NFPA-704 M Rating System):Health 3, Flammability 1, Reactivity 0. Soluble in water.

Chemical Properties

OMPA is a colorless liquid in crude form; otherwise, it is a dark brown viscous liquid.

Uses

Insecticide.

Definition

ChEBI: Schradan is a phosphorodiamide.

General Description

Schradan, octamethyl pyrophosphoramide(OMPA), bis[bisdimethylaminophosphonous] anhydride(Pestox III), is a viscous liquid that is miscible with waterand soluble in most organic solvents. It is not hydrolyzed byalkalies or water but is hydrolyzed by acids. Schradan isused as a systemic insecticide for plants, being absorbed bythe plants without appreciable injury. Insects feeding on theplant are incapacitated.
Schradan is a weak inhibitor of cholinesterases in vitro.In vivo, it is metabolized to the very strong inhibitor hydroxymethylOMPA. Hydroxymethyl OMPA is not stable andis metabolized further to the N-methoxide, which is a weakinhibitor of cholinesterase.

General Description

Dark brown viscous liquid. Used as an insecticide and as an acaricide. Not registered as a pesticide in the U.S.

Reactivity Profile

Organophosphates, such as SCHRADAN, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Health Hazard

Extremely toxic; probable oral lethal dose in humans is 5-50 mg/kg, between 7 drops and 1 teaspoonful for a 150 lb. person. It is highly toxic when inhaled. Material is a cholinesterase inhibitor. It is similar in action to other organophosphorous pesticides in its toxicity. It is slightly less toxic than parathion. Gastrointestinal, neurologic and respiratory symptoms may accompany poisoning with SCHRADAN. High doses may cause a toxic psychosis similar to acute alcoholism. Persons taking phenobarbital and phenaglycodol together, glutethimide, chlorpromazine hydrochloride, or meprobamate may be at greater risk. These drugs appear to enhance the toxicity of the material markedly.

Fire Hazard

When heated to decomposition, SCHRADAN can emit highly toxic fumes of oxides of phosphorus. Decomposes when mixed with acid. Hydrolyzed under acid conditions to dimethylamine and orthophosphoric acid.

Safety Profile

Poison by ingestion, inhalation,skin contact, intraperitoneal, intravenous, subcutaneous,and ocular routes. Human systemic effects by ingestion: acholinesterase inhibitor. Has been found to inhibitperipheral cholinesterase without pronounced effects o

Potential Exposure

Material is used as a systemic insecticide for plants and as an acaricide. Not registered as a pesticide in the United States.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Speed in removing material from skinis of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this chemicalhas been inhaled, remove from exposure, begin rescuebreathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart actionhas stopped. Transfer promptly to a medical facility. Whenthis chemical has been swallowed, get medical attention.Give large quantities of water and induce vomiting. Do notmake an unconscious person vomit. Obtain authorizationand/or further instructions from the local hospital for administration of an antidote or performance of other invasiveprocedures.Note to physician: 1,10-trimethylenebis(4-formylpyridiniumbromide)dioxime (a.k.a TMB-4 dibromide and TMV-4) hasbeen used as an antidote for organophosphate poisoning.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area away from acids. Where possible, automatically transfer from drums or other storage containers toprocess containers.

Shipping

UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Incompatibilities

Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides and active metals. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Acids.

Waste Disposal

In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Description

The recombinant form was found to be undistinguishable from the wild type when examined by SDS-PAGE and gel filtration chromatography yielding a 50.5 kDa monomeric protein. The immunological similarity of the protein samples was demonstrated by employing polyclonal and monoclonal antibodies in ELISA and Western Blot techniques. All forms of A-protein were found to activate the secretion of tumour necrosis factor alpha from murine macrophage. For ref see Maurice et al. (1999) Protein Expression and Purification 16, 396-404.
The OmpA is purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

The OmpA protein is one of the main outer-membrane proteins of a large array of Gram-negative bacteria such as A.salmonicida, Shigella dysenteriae and E.coli.OmpA’s major physiological functions include maintenance of the structural integrity and morphology of the cells and porin activity, as well as a role in conjugation and bacteriophage binding.Achromogenic atypical Aeromonas salmonicida is the causative agent of goldfish ulcer disease.Virulence of this bacterium is associated with the production of a paracrystalline outer membrane A-layer protein.The species specific structural gene for the monomeric form of A-protein was cloned into a pET-3d plasmid in order to express and produce a recombinant form of the protein in E.coli BL21(DE3). The induced protein was isolated from inclusion bodies by a simple solubilization-renaturation procedure and purified by ion exchange chromatography on Q-Sepharose to over 95% pure monomeric protein.Recombinant A-protein was compared by biochemical, immunological and molecular methods with the A-protein isolated from atypical A.salmonicida bacterial cells by the glycine and the membrane extraction methods.

SCHRADAN(152-16-9)Related Product Information

• PHOSPHAMIDON
• SCHRADAN