METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE Chemical Properties

Melting point:

208-210℃

Boiling point:

399.7±22.0 °C(Predicted)

Density 

1.709

storage temp. 

2-8°C

pka

10.67±0.40(Predicted)

Appearance

off-white solid

InChI

InChI=1S/C9H7BrN2O2/c1-14-9(13)8-6-4-5(10)2-3-7(6)11-12-8/h2-4H,1H3,(H,11,12)

InChIKey

WVNKCZKRGOOMNU-UHFFFAOYSA-N

SMILES

N1C2=C(C=C(Br)C=C2)C(C(OC)=O)=N1

Safety Information

HS Code 

2933998090

METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE Usage And Synthesis

Uses

Methyl 5-bromo-1H-indazole-3-carboxylate is an indole azole compound containing a five-membered heteroaromatic ring structure and can be used in organic synthesis. Its derivatives can also be used to treat or prevent herpes virus infection in patients.

Synthesis

Step 2: Concentrated sulfuric acid (1 mL) was slowly added to a suspension of 5-bromo-1H-indazole-3-carboxylic acid (1.30 g, 5.39 mmol) in anhydrous methanol (50 mL) under argon protection. The reaction mixture was heated to reflux for 4 hours. Upon completion of the reaction, the solution was cooled to room temperature and subsequently evaporated under reduced pressure to remove methanol. The residue was dissolved in ethyl acetate and washed with deionized water. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated to afford methyl 5-bromo-1H-indazole-3-carboxylate (1.35 g, 5.29 mmol, 98% yield) as a white solid. The product was confirmed by 1H NMR (DMSO-d6): δ 14.13 (s, 1H), 8.21 (d, J = 1.6 Hz, 1H), 7.67 (d, J = 7.2 Hz, 1H), 7.59 (dd, J = 7.2, 1.2 Hz, 1H), 3.92 (s, 3H); ESIMS analysis result: C9H7BrN2O2 m/z 256.0 (M + H).

References

[1] Patent: WO2013/40215, 2013, A1. Location in patent: Paragraph 00340
[2] Patent: US2015/266825, 2015, A1. Location in patent: Paragraph 1359; 1361
[3] Patent: WO2018/75858, 2018, A1. Location in patent: Paragraph 0371; 0373
[4] European Journal of Organic Chemistry, 2007, # 29, p. 4909 - 4916
[5] Patent: CN107573327, 2018, A. Location in patent: Paragraph 0071; 0072; 0073; 0074

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