METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE
- Product Name
- METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE
- CAS No.
- 78155-74-5
- Chemical Name
- METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE
- Synonyms
- Methyl 5-bromo-1H-indazol...;5-Bromo-3-(methoxycarbonyl)-1H-indazole;METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE;1H-Indazole-3-carboxylicacid,5-broMo-,Methylester;5-Bromo-1H-indazole-3-carboxylic acid methyl ester
- CBNumber
- CB1241488
- Molecular Formula
- C9H7BrN2O2
- Formula Weight
- 255.07
- MOL File
- 78155-74-5.mol
METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE Property
- Melting point:
- 208-210℃
- Boiling point:
- 399.7±22.0 °C(Predicted)
- Density
- 1.709
- storage temp.
- 2-8°C
- pka
- 10.67±0.40(Predicted)
- Appearance
- off-white solid
- InChI
- InChI=1S/C9H7BrN2O2/c1-14-9(13)8-6-4-5(10)2-3-7(6)11-12-8/h2-4H,1H3,(H,11,12)
- InChIKey
- WVNKCZKRGOOMNU-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(Br)C=C2)C(C(OC)=O)=N1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M295953
- Product name
- Methyl5-bromo-1H-indazole-3-carboxylate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 284636
- Product name
- Methyl 5-bromo-1H-indazole-3-carboxylate
- Packaging
- 100mg
- Price
- $379
- Updated
- 2021/12/16
- Product number
- CS-W008961
- Product name
- Methyl5-bromo-1H-indazole-3-carboxylate
- Purity
- 97.58%
- Packaging
- 10g
- Price
- $291
- Updated
- 2021/12/16
- Product number
- CS-W008961
- Product name
- Methyl5-bromo-1H-indazole-3-carboxylate
- Purity
- 97.58%
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
- Product number
- CS-W008961
- Product name
- Methyl5-bromo-1H-indazole-3-carboxylate
- Purity
- 97.58%
- Packaging
- 5g
- Price
- $168
- Updated
- 2021/12/16
METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE Chemical Properties,Usage,Production
Uses
Methyl 5-bromo-1H-indazole-3-carboxylate is an indole azole compound containing a five-membered heteroaromatic ring structure and can be used in organic synthesis. Its derivatives can also be used to treat or prevent herpes virus infection in patients.
Synthesis
1077-94-7
67-56-1
78155-74-5
Step 2: Concentrated sulfuric acid (1 mL) was slowly added to a suspension of 5-bromo-1H-indazole-3-carboxylic acid (1.30 g, 5.39 mmol) in anhydrous methanol (50 mL) under argon protection. The reaction mixture was heated to reflux for 4 hours. Upon completion of the reaction, the solution was cooled to room temperature and subsequently evaporated under reduced pressure to remove methanol. The residue was dissolved in ethyl acetate and washed with deionized water. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated to afford methyl 5-bromo-1H-indazole-3-carboxylate (1.35 g, 5.29 mmol, 98% yield) as a white solid. The product was confirmed by 1H NMR (DMSO-d6): δ 14.13 (s, 1H), 8.21 (d, J = 1.6 Hz, 1H), 7.67 (d, J = 7.2 Hz, 1H), 7.59 (dd, J = 7.2, 1.2 Hz, 1H), 3.92 (s, 3H); ESIMS analysis result: C9H7BrN2O2 m/z 256.0 (M + H).
References
[1] Patent: WO2013/40215, 2013, A1. Location in patent: Paragraph 00340
[2] Patent: US2015/266825, 2015, A1. Location in patent: Paragraph 1359; 1361
[3] Patent: WO2018/75858, 2018, A1. Location in patent: Paragraph 0371; 0373
[4] European Journal of Organic Chemistry, 2007, # 29, p. 4909 - 4916
[5] Patent: CN107573327, 2018, A. Location in patent: Paragraph 0071; 0072; 0073; 0074
METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE manufacturers
- Product
- Methyl 5-bromo-1H-indazole-3-carboxylate 78155-74-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%min
- Supply Ability
- 1-10000kgs
- Release date
- 2023-04-17
- Product
- METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE 78155-74-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09