1H-indazole-3-carboxylic acid methyl ester
- Product Name
- 1H-indazole-3-carboxylic acid methyl ester
- CAS No.
- 43120-28-1
- Chemical Name
- 1H-indazole-3-carboxylic acid methyl ester
- Synonyms
- TIMTEC-BB SBB009999;Lonidamine Impurity 1;Methyl 1H-indazole-3-carb...;methyl indazole-3-carboxylate;Methyl 3-indole-3-carboxylate;METHYL INDAZOLYL-3-CARBOXYLATE;METHYL 1H-INDAZOLE-3-CARBOXYLATE;1h-indazole-3-methyl carboxylate;3-Indazolecarboxylic acid methyl ester;Indazole-3-carboxylic Acid Methyl Ester
- CBNumber
- CB3474521
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 43120-28-1.mol
1H-indazole-3-carboxylic acid methyl ester Property
- Melting point:
- 162-163℃
- Boiling point:
- 345.2±15.0 °C(Predicted)
- Density
- 1.324
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 11.93±0.40(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I505250
- Product name
- Indazole-3-carboxylicAcidMethylEster
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 4H58-1-BA
- Product name
- Methyl 1H-indazole-3-carboxylate
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 072855
- Product name
- 1H-Indazole-3-carboxylic acid methyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- W6261
- Product name
- 1H-Indazole-3-carboxylicacidmethylester
- Packaging
- 5g
- Price
- $21
- Updated
- 2021/12/16
- Product number
- 072855
- Product name
- 1H-Indazole-3-carboxylic acid methyl ester
- Purity
- 95+%
- Packaging
- 5g
- Price
- $24
- Updated
- 2021/12/16
1H-indazole-3-carboxylic acid methyl ester Chemical Properties,Usage,Production
Uses
Indazole-3-carboxylic Acid Methyl Ester has potential as application of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. Also used in the preparation of indazole-pyridine based protain kinase/Akt inhibitors.
Definition
ChEBI: 1H-indazole-3-carboxylic acid methyl ester is a member of indazoles.
Synthesis
67-56-1
4498-67-3
43120-28-1
Indazole-3-carboxylic acid (5.0 g, 30.8 mmol) was dissolved in methanol (50 mL) at 0 °C and thionyl chloride (15 mL) was added slowly and dropwise. After the dropwise addition was completed, the reaction mixture was heated to reflux temperature and maintained at this temperature for 1.5 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to give the crude product. The crude product was neutralized by adding saturated sodium bicarbonate solution (50 mL) to the crude product and subsequently extracted with ethyl acetate (50 mL x 3). The organic phases were combined and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to afford methyl 1H-indazole-3-carboxylate as a white solid (5.1 g, 94% yield). The NMR hydrogen spectrum (300 MHz, d6-DMSO) data were as follows: δ 13.91 (s, 1H), 8.06 (d, J = 8.2 Hz, 1H), 7.65 (d, J = 8.4 Hz, 1H), 7.44 (ddd, J = 8.3 Hz, 6.9 Hz, 1.1 Hz, 1H), 7.30 (dd, J = 7.9 Hz, 6.9 Hz, 0.9 Hz, 1H), 3.92 (s, 3H).
References
[1] Tetrahedron Letters, 2007, vol. 48, # 14, p. 2457 - 2460
[2] Chemical Communications, 2010, vol. 46, # 33, p. 6165 - 6167
[3] ChemMedChem, 2017, vol. 12, # 19, p. 1578 - 1584
[4] Patent: WO2013/120104, 2013, A2. Location in patent: Paragraph 00210; 00211
[5] RSC Advances, 2015, vol. 5, # 100, p. 81817 - 81830
1H-indazole-3-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-indazole-3-carboxylic acid methyl ester manufacturers
- Product
- 1H-indazole-3-carboxylic acid methyl ester 43120-28-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-12
- Product
- Methyl1H-indazole-3-carboxylate 43120-28-1
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-05-04
- Product
- 1h-indazole-3-methyl carboxylate 43120-28-1
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 99.99%
- Supply Ability
- 10T
- Release date
- 2025-02-20