ChemicalBook > CAS DataBase List > 1H-indazole-3-carboxylic acid methyl ester

1H-indazole-3-carboxylic acid methyl ester

Product Name: 1H-indazole-3-carboxylic acid methyl ester
CAS No.: 43120-28-1
Chemical Name: 1H-indazole-3-carboxylic acid methyl ester
Synonyms: TIMTEC-BB SBB009999;Lonidamine Impurity 1;Methyl 1H-indazole-3-carb...;methyl indazole-3-carboxylate;Methyl 3-indole-3-carboxylate;METHYL INDAZOLYL-3-CARBOXYLATE;METHYL 1H-INDAZOLE-3-CARBOXYLATE;1h-indazole-3-methyl carboxylate;3-Indazolecarboxylic acid methyl ester;Indazole-3-carboxylic Acid Methyl Ester
CBNumber: CB3474521
Molecular Formula: C9H8N2O2
Formula Weight: 176.17
MOL File: 43120-28-1.mol

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1H-indazole-3-carboxylic acid methyl ester Property

Melting point:: 162-163℃
Boiling point:: 345.2±15.0 °C(Predicted)
Density: 1.324
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 11.93±0.40(Predicted)
color: White to Off-White

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: I505250
Product name: Indazole-3-carboxylicAcidMethylEster
Packaging: 5g
Price: $110
Updated: 2021/12/16

Matrix Scientific

Product number: 072855
Product name: 1H-Indazole-3-carboxylic acid methyl ester
Purity: 95+%
Packaging: 1g
Price: $10
Updated: 2021/12/16

AK Scientific

Product number: W6261
Product name: 1H-Indazole-3-carboxylicacidmethylester
Packaging: 5g
Price: $21
Updated: 2021/12/16

Matrix Scientific

Product number: 072855
Product name: 1H-Indazole-3-carboxylic acid methyl ester
Purity: 95+%
Packaging: 5g
Price: $24
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-BA
Product name: Methyl 1H-indazole-3-carboxylate
Packaging: 1g
Price: $25
Updated: 2021/12/16

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1H-indazole-3-carboxylic acid methyl ester Chemical Properties,Usage,Production

Uses

Indazole-3-carboxylic Acid Methyl Ester has potential as application of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. Also used in the preparation of indazole-pyridine based protain kinase/Akt inhibitors.

Definition

ChEBI: 1H-indazole-3-carboxylic acid methyl ester is a member of indazoles.

Synthesis

67-56-1

4498-67-3

43120-28-1

Indazole-3-carboxylic acid (5.0 g, 30.8 mmol) was dissolved in methanol (50 mL) at 0 °C and thionyl chloride (15 mL) was added slowly and dropwise. After the dropwise addition was completed, the reaction mixture was heated to reflux temperature and maintained at this temperature for 1.5 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to give the crude product. The crude product was neutralized by adding saturated sodium bicarbonate solution (50 mL) to the crude product and subsequently extracted with ethyl acetate (50 mL x 3). The organic phases were combined and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to afford methyl 1H-indazole-3-carboxylate as a white solid (5.1 g, 94% yield). The NMR hydrogen spectrum (300 MHz, d6-DMSO) data were as follows: δ 13.91 (s, 1H), 8.06 (d, J = 8.2 Hz, 1H), 7.65 (d, J = 8.4 Hz, 1H), 7.44 (ddd, J = 8.3 Hz, 6.9 Hz, 1.1 Hz, 1H), 7.30 (dd, J = 7.9 Hz, 6.9 Hz, 0.9 Hz, 1H), 3.92 (s, 3H).

References

[1] Tetrahedron Letters, 2007, vol. 48, # 14, p. 2457 - 2460
[2] Chemical Communications, 2010, vol. 46, # 33, p. 6165 - 6167
[3] ChemMedChem, 2017, vol. 12, # 19, p. 1578 - 1584
[4] Patent: WO2013/120104, 2013, A2. Location in patent: Paragraph 00210; 00211
[5] RSC Advances, 2015, vol. 5, # 100, p. 81817 - 81830

1H-indazole-3-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-indazole-3-carboxylic acid methyl ester manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1H-indazole-3-carboxylic acid methyl ester 43120-28-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-12

RongNa Biotechnology Co.,Ltd

Product: Methyl1H-indazole-3-carboxylate 43120-28-1
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 100kg
Release date: 2025-05-04

Shandong Xuhuang New material CoLTD

Product: 1h-indazole-3-methyl carboxylate 43120-28-1
Price: US $20.00/KG
Min. Order: 1KG
Purity: 99.99%
Supply Ability: 10T
Release date: 2025-02-20

43120-28-1, 1H-indazole-3-carboxylic acid methyl ester Related Search:

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Methyl 1H-indazole-3-carb...

1H-Indazole-3-Carboxylic Acid Methyl Ester(WX6

Indazole-3-carboxylic Acid Methyl Ester

TIMTEC-BB SBB009999

METHYL INDAZOLYL-3-CARBOXYLATE

METHYL 1H-INDAZOLE-3-CARBOXYLATE

1H-Indazole-3-Carboxylic Acid Methyl Ester(WX618179)

methyl indazole-3-carboxylate

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Lonidamine Impurity 1

43120-28-1