1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE Chemical Properties

Melting point:

75-77°

Boiling point:

267.83°C (rough estimate)

Density 

1.0558 (rough estimate)

refractive index 

1.5100 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Very Slightly)

form 

Solid

color 

White or yellowish leafy crystals.

LogP

2.25

EPA Substance Registry System

3-Buten-2-one, 4-(4-methoxyphenyl)- (943-88-4)

Safety Information

HazardClass 

IRRITANT

HS Code 

2914500090

Toxicity

Both the acute oral LD₅₀ value in rats and the acute dermal LD₅₀ value in rabbits exceeded 5 g/kg (Wohl, 1974).

1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE Usage And Synthesis

Aroma

Slightly pungent, but in dilution sweet, floral and creamy odor of considerable tenacity. 
1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE, like many related ketones, has met with much resistance from perfumers and dermatologists. However, it has survived all attacks under the usual and probably reasonable argument, that in normal concentrations, it will have no harmful effects on the human skin. Undoubtedly, perfumers are using scores of materials with a much shorter history of successful application.
It finds use in many floral perfume compositions, mainly Cassie bases, Acacia, Lilac, Sweet Pea, Hyacinth, etc. In even lower concentration, it may give interesting effects in Lavender, Fougeres, New Mown Hay (for which it was originally intended), etc.

Occurrence

Has apparently not been reported to occur in nature.

Uses

4-(4-methoxyphenyl)-3-buten-2-one is used in preparation of Thiazole derivatives as protein secretion inhibitors.

Preparation

From anisaldehyde and acetone by condensation using a suitable catalyst.

Metabolism

When the side chain of a mixed ketone contains a double bond, both the keto group and the double bond are potentially reducible in vivo. In a related material, methyl styryl ketone ( C₆ H₅ CH:CHCOCH₃ ) , the keto group appears to be more readily reduced than the double bond,with reduction via C₆ H₅ CH:CH.CH(OH)CH₃to the completely reduced carbinol compoundC₆ H₅[CH₂]₂CH(OH) CH₃, which is found as the main product (Fischer & Bielig, 1940). The ether link is relatively stable in substituted anisoles, such as anethole (p-CH₃OC ₆H₄CH:CH CH₄), containinga potential carboxyl group attached to the aromatic ring (Williams, 1959).

1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE(943-88-4)Related Product Information

• 1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE,4-(4-METHOXYPHENYL)-3-BUTEN-2-ONE,4-(P-METHOXYPHENYL)-3-BUTEN-2-ONE
• Vanillylidenacetone
• Benzylacetone
• 3-methyl-4-(4-methoxyphenyl)-3-buten-2-one
• trans-4-(4-Methoxyphenyl)-3-buten-2-one
• 3-METHOXYBENZALACETONE
• 3,4-Bis(p-methoxyphenyl)-3-buten-2-one
• (2Z)-1,3-Bis(4-methoxyphenyl)-2-buten-1-one
• 3-(4-methoxyanilino)-1-(4-methoxyphenyl)-2-buten-1-one
• 4-(m-Methoxyphenyl)-3-buten-2-one semicarbazone
• (E)-1-(4-Methoxyphenyl)-2-buten-1-one
• 1-(1,3-Dithian-2-ylidene)-4-(4-methoxyphenyl)-3-buten-2-one
• 4-(o-Methoxyphenyl)-3-buten-2-one semicarbazone
• 4-(2-HYDROXY-3-METHOXYPHENYL)-3-BUTEN-2-ONE
• 1-(1,3-Dithiolan-2-ylidene)-4-(4-methoxyphenyl)-3-buten-2-one
• 4-(p-Methoxyphenyl)-3-buten-2-one semicarbazone
• 2-METHOXYBENZALACETONE
• (Z)-3-(DIMETHYLAMINO)-1-(4-METHOXYPHENYL)-2-BUTEN-1-ONE