RO 0437626
RO 0437626 Basic information
- Product Name:
- RO 0437626
- Synonyms:
-
- RO 0437626
- N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide
- 1H-Benzimidazole-2-carboxamide, N-[(1R)-2-[[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-
- CAS:
- 134362-79-1
- MF:
- C27H35N5O4S
- MW:
- 525.66
- Mol File:
- 134362-79-1.mol
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RO 0437626 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble to 100 mM in DMSO and to 100 mM in ethanol
- form
- Powder
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RO 0437626 Usage And Synthesis
Uses
Ro 0437626 is a P2X1 purinergic receptor antagonist.
Biological Activity
Selective P2X 1 purinergic receptor antagonist (IC 50 = 3 μ M) that displays > 30-fold selectivity over P2X 2 , P2X 3 and P2X 2/3 receptors (IC 50 > 100 μ M).
in vivo
Ro 0437626 (1 and 10 μmol/kg; i.v.) causes a reduction in postinfusion isovolumetric contractions[3].
| Animal Model: | Female rat (urethane-anaesthetized)[3] |
| Dosage: | 1 and 10 μmol/kg |
| Administration: | I.v. |
| Result: | Caused a reduction in postinfusion isovolumetric contractions. |
RO 0437626Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
EMMX Biotechnology LLC
- Tel
- 888-539-0666
- info@emmx.com
Shanghai Han-Xiang Chemical Co., Ltd.
- Tel
- 15971444841
- amber@biochempartner.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
BOC Sciences
- Tel
- info@bocsci.com