4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine Chemical Properties

Melting point:

197.0 to 201.0 °C

Boiling point:

476.7±45.0 °C(Predicted)

Density 

1.532

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

-0.65±0.41(Predicted)

color 

White to Almost white

CAS DataBase Reference

607740-08-9

Safety Information

HS Code 

2933.59.8000

4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine Usage And Synthesis

Uses

4-(3,5-dibromophenyl)-2,6-diphenylpyrimidine is an organic intermediate that can be prepared in two steps by reacting 3,5-dibromobenzaldehyde, acetophenone and benzamide hydrochloride.

Synthesis

3,5-dibromobenzaldehyde (1.0 g, 40 mmol), acetophenone (4.81 g, 40 mmol) were used as raw materials, which were dissolved in ethanol (80 mL), followed by addition of sodium hydroxide (0.16 g, 4 mmol). The reaction mixture was stirred at room temperature for 8 hours. Upon completion of the reaction, benzylcarbamidine hydrochloride (4.70 g, 30 mmol), sodium hydroxide (1.60 g, 40 mmol) and ethanol (40 mL) were added to the system and the reaction mixture was heated to reflux and the reaction was continued for 8 hours. At the end of the reaction, the resulting white solid was collected by filtration and washed with ethanol until the filtrate was colorless. The solid product was further washed with water and ethanol and finally dried under vacuum to give intermediate N (5.20 g, yield: 56%).

References

[1] Patent: EP2662368, 2013, A1. Location in patent: Paragraph 0183; 0184

4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine(607740-08-9)Related Product Information

• Xylene
• 4-BENZYLOXYPHENYL MAGNESIUM BROMIDE
• 2,4-Diamino-6-hydroxypyrimidine