2,4-Diamino-6-hydroxypyrimidine Chemical Properties

Melting point:

285-286 °C (dec.) (lit.)

Boiling point:

234.22°C (rough estimate)

Density 

1.3659 (rough estimate)

refractive index 

1.7990 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

10.61±0.50(Predicted)

form 

Fine Crystalline Powder

color 

White to cream

Sensitive 

Light Sensitive

Merck 

14,2981

BRN 

125006

InChIKey

SWELIMKTDYHAOY-UHFFFAOYSA-N

CAS DataBase Reference

56-06-4(CAS DataBase Reference)

NIST Chemistry Reference

4(1H)-pyrimidinone, 2,6-diamino-(56-06-4)

EPA Substance Registry System

2,6-Diamino-4(1H)-pyrimidinone (56-06-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29335995

MSDS

• Language:English Provider:2,4-Diamino-6-hydroxypyrimidine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,4-Diamino-6-hydroxypyrimidine Usage And Synthesis

Description

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC₅₀ for inhibition of BH₄ biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.

Chemical Properties

White Solid

Uses

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.[Cayman Chemical]

Uses

It stands at the beginning of the enzyme-catalyzed cascade that starts with this seven-carbon carbohydrate and ends with the aromatic amino acids phenylalanine, tyrosine, and tryptophan

Uses

2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) is a compound useful in organic synthesis.

storage

+4°C

Purification Methods

It recrystallises from H2O. [Beilstein 25 III/IV 3642.]

2,4-Diamino-6-hydroxypyrimidine(56-06-4)Related Product Information

• Triclosan
• 1,3-Dihydroxyacetone
• 4,4'-Methylenedianiline
• Iminodiacetic acid
• 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL
• 4-Hydroxy-6-aminopyrimidine
• 1-Hydroxyethylidene-1,1-diphosphonic acid
• 1,3-Diaminoguanidine monohydrochloride
• Iminodiacetonitrile
• 4-[2’-(7’’-Deazaguanine)ethyl]benzoic Acid N-Hydroxysuccinimide Ester
• Methyl 4-(4-oxobutyl)benzoate
• N-[4-[3-(2,6-DiaMino-1,4-dihydro-4-oxo-5-pyriMidinyl)-3-oxopropyl]benzoyl]-L-glutaMic Acid
• 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid
• 3-Buten-1-ol
• PeMetrexed IMpurity D
• PeMetrexed EP IMpurity C
• Methyl 4-bromobenzoate
• Benzoic acid, 4-(1-methyl-3-oxopropyl)-, methyl ester (9CI)