1-Hydroxyethylidene-1,1-diphosphonic acid
1-Hydroxyethylidene-1,1-diphosphonic acid Basic information
- Product Name:
- 1-Hydroxyethylidene-1,1-diphosphonic acid
- Synonyms:
-
- ETHANE-1-HYDROXY-1,1-DIPHOSPHONIC ACID, 95+%
- (1-Hydroxyethylidene)biphosphonic acid
- Hydroxyethylidene Diphosphonic acid (HEDP)
- 1-Hydroxyethylidene-1,1-diphosphonicacid,min.95%HEDP
- 1-Hydroxyethan-1,1-diphosphonsure
- 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID HEDP
- 1-Hydroxyethylidene-1,1-bis-(phosphonic acid)
- 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID, 98% HEDP
- CAS:
- 2809-21-4
- MF:
- C2H8O7P2
- MW:
- 206.03
- EINECS:
- 220-552-8
- Product Categories:
-
- Phosphonate antiscalant
- Analytical Chemistry
- Industrial/Fine Chemicals
- INORGANIC & ORGANIC CHEMICALS
- Ligands for Pharmaceutical Research
- Radiopharmaceutical Chemistry (Chelating Reagents)
- organophosphorus compound
- Water treatment
- Mol File:
- 2809-21-4.mol
1-Hydroxyethylidene-1,1-diphosphonic acid Chemical Properties
- Melting point:
- 198~199℃
- Boiling point:
- 578.8±60.0 °C(Predicted)
- Density
- 1.45 (60% aq.)
- form
- Powder
- pka
- 1.35, 2.87, 7.03, 11.3(at 25℃)
- color
- white
- PH
- pH (1.7→100, 25℃) : 1.3~1.8
- Water Solubility
- Soluble in water.
- Merck
- 14,3863
- BRN
- 1789291
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- DBVJJBKOTRCVKF-UHFFFAOYSA-N
- CAS DataBase Reference
- 2809-21-4(CAS DataBase Reference)
- EPA Substance Registry System
- Etidronic acid (2809-21-4)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 37/38-41-22
- Safety Statements
- 26-39
- RIDADR
- UN 3265
- WGK Germany
- 2
- RTECS
- SZ8562100
- F
- 10
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29319090
- Hazardous Substances Data
- 2809-21-4(Hazardous Substances Data)
- Toxicity
- LD50 oral in mouse: 1800mg/kg
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
1-Hydroxyethylidene-1,1-diphosphonic acid Usage And Synthesis
Chemical Properties
light beige powder
Originator
Etidron,Gentili,Italy,1977
Uses
Etidronate (Didronel) is a human protein tyrosine phosphatase inhibitor with IC50 of 0.2 μM.
Definition
ChEBI: A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.
Manufacturing Process
Phosphorous acid was premixed with acetic acid to form a 50 wt % solution of phosphorous acid dissolved in acetic acid. The acids were mixed on a molar basis of 1.36:1, acetic acid to phosphorous acid, and this corresponded on a mol percentage basis to 57.6% acetic acid and 42.4% phosphorous acid. Acetic anhydride was continuously metered into a stream of the phosphorous acid-acetic acid mixture to form the reaction solution. The acetic anhydride was metered into the acid mixture at a mol ratio of 1.33 mols of acetic anhydride per mol of phosphorous acid. The metering rates were 18.5 lb/hr of the phosphorous acid/acetic acid premixed solution and 15.1 lb/hr acetic anhydride. The reaction solution was continuously passed through a heat exchanger where it was heated to 190°F then it was continuously fed into a two stage back-mix reaction zone where due to the heat of reaction the temperature rose to 275°F. The average residence in the reaction zone was 27 min. The reaction zone consisted of two back-mix reactors each having a capacity of 7.5 pounds of the reaction solution. A stream of reaction solution was continuously with drawn from the second reactor and continuously mixed with a stream of water which was being metered at a rate of 2 lb/hr. This amount of water corresponded to 18% excess over the theoretical amount necessary to hydrolyze all of the acetyl-containing compounds in the reaction solution to free acids. The hydrolyzed solution was continuously passed through a heat exchanger and cooled to room temperature after which the solution was continuously passed to a crystallizer where, with agitation, the ethane-1-hydroxy-1,1-diphosphonic acid crystallized. The slurry was then filtered and the crystals were recovered and dried. Analysis of the product showed a conversion rate of phosphorous acid to ethane-1-hydroxy-1,1- diphosphonic acid of 86%. Sodium hydroxide may be used to give the disodium salt.
brand name
Didronel (Millot Laboratories, France); Didronel (Procter & Gamble).
Therapeutic Function
Bone calcium regulator
1-Hydroxyethylidene-1,1-diphosphonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1-Hydroxyethylidene-1,1-diphosphonic acid Supplier
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1-Hydroxyethylidene-1,1-diphosphonic acid (2809-21-4)Related Product Information
- MINODRONATE
- 4-(4-(bis(2-chloroethyl)amino)phenyl)-1-hydroxybutane-1,1-bisphosphonic acid
- 1-Hydroxyethylidene-1,1-Diphosphonic Acid Sodium Salt
- 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID TRISODIUM SALT
- NERIDRONATE SODIUM HYDRATE
- [1-Hydroxy-3-(methylpentylamino)-propylidene]bisphosphonic acid sodium salt
- 1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID [1-14C]
- 1-Hydroxyethylidene-1,1-diphosphonic acid
- CLODRONIC ACID
- phosphoric acid
- Ascoric Acid
- Citric acid
- Glycine
- 2-HYDROXYACETAMIDE
- Amino tris(methylene phosphonic acid)
- Ethyl 2-(Chlorosulfonyl)acetate
- Disodium pamidronate
- 4'-Hydroxyacetophenone