4-Hydroxy-6-aminopyrimidine Chemical Properties

Melting point:

262-264°C

Boiling point:

227.5±43.0 °C(Predicted)

Density 

1.55±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO

form 

Solid

pka

10.04±0.40(Predicted)

color 

White

BRN 

112429

InChI

InChI=1S/C4H5N3O/c5-3-1-4(8)7-2-6-3/h1-2H,(H3,5,6,7,8)

InChIKey

HFMLLTVIMFEQRE-UHFFFAOYSA-N

SMILES

C1=NC(N)=CC(=O)N1

CAS DataBase Reference

1193-22-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-41

Safety Statements 

26-36-39

WGK Germany 

WGK 3

HazardClass 

IRRITANT

HS Code 

2933599590

Storage Class

13 - Non Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:ALFA

4-Hydroxy-6-aminopyrimidine Usage And Synthesis

Chemical Properties

White Solid

Synthesis

Step 2: 2-mercapto-4-amino-6-hydroxypyridine (mass ratio 1:15) was added to 25% ammonia, followed by the addition of activated nickel and titanium dioxide, wherein the molar ratio of 2-mercapto-4-amino-6-hydroxypyridine, activated nickel and titanium dioxide was 1:4:1.5. The mixture was heated to 90°C and the reaction was carried out at reflux for 5 hours. Upon completion of the reaction, the activated nickel and titanium dioxide were removed by thermal filtration. The filtrate was cooled to room temperature and the solid product was precipitated. The solid was washed with 30 mL of water and dried at 40 °C to afford 4-amino-6-hydroxypyrimidine in 98.4% yield.

References

[1] Patent: CN105218554, 2016, A. Location in patent: Paragraph 0023
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 9, p. 1918 - 1929
[3] Patent: EP1406911, 2016, B1. Location in patent: Paragraph 00382; 00383

4-Hydroxy-6-aminopyrimidine(1193-22-2)Related Product Information

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• 5-Bromo-4,6-dihydroxypyrimidine
• 2-Methylthio-4,6-pyrimidinedione
• 2,4-Diamino-6-hydroxypyrimidine ,98%
• 4-Hydroxy-6-aminopyrimidine
• ETRIMFOS
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• 4,5-DIAMINO-6-HYDROXYPYRIMIDINE SULFATE
• 2-Amino-4,6-dimethoxypyrimidine
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• 4,5-DIAMINO-6-HYDROXYPYRIMIDINE HEMISULFATE
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• 4,6-DIHYDROXY-5-NITROPYRIMIDINE