2-(methylthio)pyrimidine-4,6-diol Chemical Properties

Melting point:

>300 °C(lit.)

Density 

1.55±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Ethyl Acetate, Ethanol, Methanol

form 

Powder

pka

4.06±0.10(Predicted)

color 

White

CAS DataBase Reference

1979-98-2(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

2

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich

2-(methylthio)pyrimidine-4,6-diol Usage And Synthesis

Chemical Properties

White Solid

Uses

2-(Methylthio)-4,6-pyrimidinediol (cas# 1979-98-2) is a compound useful in organic synthesis.

Synthesis

Step a: Synthesis of 2-methylthio-pyrimidine-4,6-diol (19a); Iodomethane (32.64 g, 220 mmol) was slowly added dropwise to a suspension of thiobarbituric acid (29 g, 200 mmol) dissolved in ethanol (300 mL) and 2M aqueous sodium hydroxide (110 mL) at room temperature. The reaction mixture was stirred overnight at room temperature, followed by warming to 60 °C and continued stirring for 2 hours. Upon completion of the reaction, ethanol was removed by distillation under reduced pressure, an appropriate amount of water was added and the mixture was cooled in an ice bath for 2 hours. The precipitated solid 4,6-dihydroxy-2-methylmercaptopyrimidine was collected by filtration, washed with ice water and dried to give the product (30 g, 95% yield).

References

[1] Patent: WO2008/95999, 2008, A1. Location in patent: Page/Page column 96
[2] Patent: WO2012/97478, 2012, A1. Location in patent: Page/Page column 58-59

2-(methylthio)pyrimidine-4,6-diol(1979-98-2)Related Product Information

• 4,6-Dihydroxypyrimidine
• 3-Mercaptopropionic acid
• Pyrimidine
• ISOMETHIOZIN
• 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL
• Methimazole
• Mercaptoacetic acid
• Succimer
• Nuclomedone
• 2-Mercaptoethanol
• 2-Methylsulfonyl-4,6-dimethoxypyrimidine
• 4,6-Dimethoxy-2-methylthiopyrimidine
• 4,6-Dihydroxy-2-methythiopyrimidine
• 4-Hydroxypyrimidine
• 4,6-DIMETHOXY-2-METHYLSULFINYLPYRIMIDINE
• CHEMBRDG-BB 6979119
• 2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)THIO]BENZOIC ACID
• CHEMBRDG-BB 5930279