- Product Name:
- 2-Mercapto-1-methylimidazole ,98%
- Pinacidil monohydrate,(±)-N-Cyano-N′-4-pyridinyl-N″-(1,2,2-trimethylpropyl)guanidine monohydrate
- Methimazole (200 mg)
- 1-Methyl-1H-imidazole-2-thiol, 2-Mercapto-1-methyl-1H-imidazole
- MethiMazole(Tapazole, Northyx)
- Product Categories:
- Bioactive Small Molecules
- Building Blocks
- Cell Biology
- Chemical Synthesis
- Heterocyclic Building Blocks
- Heterocyclic Compounds
- Intermediates & Fine Chemicals
- Other APIs
- Medicine Intermediates
- Pharmaceutical intermediates
- Mol File:
Methimazole Chemical Properties
- Melting point:
- 144-147 °C(lit.)
- Boiling point:
- 280 °C
- 1.176 (estimate)
- refractive index
- 1.5000 (estimate)
- Flash point:
- storage temp.
- Crystalline Powder
- White to slightly cream or pale buff
- Water Solubility
- CAS DataBase Reference
- 60-56-0(CAS DataBase Reference)
- NIST Chemistry Reference
- EPA Substance Registry System
- 2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-(60-56-0)
Methimazole Usage And Synthesis
Methimazole is an antithyroid medication used in the therapy of hyperthyroidism and Graves disease. It works by making it harder for the body to make thyroid hormone.
It is also known as thiamazole, is a thioamide and a thyroid hormone antagonist which acts by inhibiting the incorporation of iodine into tyrosyl residues of thyroglobulin and, thus, lowering thyroid hormone levels.
It resembles propylthiouracil both in chemical structure and activity.
Methimazole is primarily used for the treatment of hyperthyroidism, by inhibiting the peroxidase system, hindering thyroxine (T4) and tri-triiodothyronine (T3) synthesis, animal experiments show that it can inhibit B lymphocytes synthesizing antibodies, and reduce levels of thyroid stimulating antibodies in blood circulating it can make suppressing T cell function return to normal, it is applicable to hyperthyroidism caused by a variety of factors . Like other various drugs (propylthiouracil), it also has some adverse reactions while it is taken, Including hematologic adverse reactions, primarily neutropenia, hematopoietic dysfunction or disorder, thrombocytopenia, reduction of prothrombin or factor VII ; long-term medication can also cause liver damage,such as cholestatic jaundice and toxic hepatitis ; other skin reactions such as hair loss, itching, rash, dermatitis, lupus erythematosus, as well as some other rare adverse reactions. Also methimazole allows prothrombin time to prolong , and increases serum alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT)and causes blood bilirubin and blood lactate dehydrogenase increasing. Therefore, patients in the medication should regularly take blood tests, liver function tests and peripheral blood leukocytes.
The above information is edited by the Chemicalbook of Tian Ye.
leaf-shaped crystalline (ethanol), melting point 146-148 ℃, boiling point 280 ℃ (decomposition), soluble in water, soluble in alcohol, chloroform, slightly soluble in ether, benzene.
React amino acetal with methyl isothiocyanate to genarate this product. The product can also be produced from thiocyanate and N-substituted amino acetal.
Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid
Tapazole (Jones); Tapazole (King) .
Methimazole, 1-methylimidazole-2-thiol (Tapazole), occurs as a white to off-white, crystallinepowder with a characteristic odor and is freely soluble inwater. A 2% aqueous solution has a pH of 6.7 to 6.9. It shouldbe packaged in well-closed, light-resistant containers.
Methimazole is indicated in the treatment of hyperthyroidism.It is more potent than propylthiouracil. The side effectsare similar to those of propylthiouracil. As with otherantithyroid drugs, patients using this drug should be undermedical supervision. Also, like the other antithyroid drugs,methimazole is most effective if the total daily dose is subdividedand given at 8-hour intervals.
Poison by subcutaneous route. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. An antithyroid drug. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also MERCAPTANS.
Veterinary Drugs and Treatments
Methimazole is considered by most clinicians to be the agent
of choice when using drugs to treat feline hyperthyroidism.
Propylthiouracil has significantly higher incidences of adverse
when compared to methimazole and is rarely used today.
Transdermal methimazole (in PLO gel; 2.5 mg twice daily) has been
used with some therapeutic success in cats that do not tolerate oral
dosing. Efficacy may require four or more weeks to detect. Studies
Methimazole appears to be useful for the prophylactic prevention of cisplatin induced nephrotoxicity in dogs.
Crystallise it from EtOH. UV: at 251nm (H2O), 260nm (EtOH) and 267nm (CHCl3). [Lawson max & Morley J Chem Soc 1103 1956, Beilstein 24 H 17, 24 III/IV 61.]
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- Methimazole Glucuronide,Methimazole Thio-b-D-glucuronide,Methimazole Glucuronid,Methimazole Thio--D-glucuronide
- THIAMAZOL IMPURITY A
- ETHYL 2-MERCAPTO-1-METHYLIMIDAZOLE-5-CARBOXYLATE
- THIAMAZOL IMPURITY C
- 2-Ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate
- Mercaptoacetic acid