Methyl isothiocyanate Chemical Properties

Melting point:

30-34 °C(lit.)

Boiling point:

117-118 °C(lit.)

Density 

1.069 g/mL at 25 °C(lit.)

vapor pressure 

21 mm Hg ( 20 °C)

FEMA 

4426 | METHYL ISOTHIOCYANATE

refractive index 

nD37 1.5258

Flash point:

90 °F

storage temp. 

2-8°C

solubility 

H2O: slightly soluble

form 

Low Melting Solid

color 

White to pale yellow

Water Solubility 

7.6 g/L

Sensitive 

Moisture Sensitive

JECFA Number

1884

Merck 

14,6092

BRN 

605319

Stability:

Stable. Incompatible with strong oxidizing agents, alcohols, strong bases, amines.

InChIKey

LGDSHSYDSCRFAB-UHFFFAOYSA-N

CAS DataBase Reference

556-61-6(CAS DataBase Reference)

NIST Chemistry Reference

Methane, isothiocyanato-(556-61-6)

EPA Substance Registry System

Methyl isothiocyanate (556-61-6)

Safety Information

Hazard Codes 

T,N

Risk Statements 

23/25-34-43-50/53

Safety Statements 

36/37-38-45-60-61

RIDADR 

UN 2477 6.1/PG 1

WGK Germany 

3

RTECS 

PA9625000

F 

21

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

I

HS Code 

29309090

Hazardous Substances Data

556-61-6(Hazardous Substances Data)

Toxicity

LD50 in rats, mice (mg/kg): 220, 110 orally; in rabbits (mg/kg): 33 dermally (Vernot); LD50 s.c. in mice: 0.05 g/kg (Klesse, Lukoschek)

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Methyl isothiocyanate Usage And Synthesis

Description

Methyl iso thio cyanate is the organo sulfur compound with the formula CH₃N = C = S . This low melting colorless solid is a powerful lachrymator. As a precursor to a variety of valuable bioactive compounds, it is the most important organic iso thio cyanate in industry.

Chemical Properties

colourless solid

Chemical Properties

Methyl isothiocyanate is a crystalline solid. Horseradish, acrid odor.

Chemical Properties

Colorless to tan liquid; pungent, penetrating, mustard-like odor.

Occurrence

Reported found in horseradish.

Uses

Usually used to study the effect of pesticide Metam (methyl isothiocyanate is its active ingredient) in the streamside microbial communities of the upper Sacramento river

Uses

Pesticide; soil fumigant.

Uses

Pesticide and soil fumigant used to control insects, soil fungi, nematodes.

Application

Solutions of MITC are used in agriculture as soil fumigants, mainly for protection against fungi and nematodes.
MITC is a building block for the synthesis of 1,3,4 - thiadiazoles, which are heterocyclic compounds used as herbicides. Commercial products include "Spike", "Ustilan," and "Erbotan." Well known pharmaceuticals prepared using MITC include Zantac and Tagamet.

Definition

ChEBI: An isothiocyanate having a methyl group attached to the nitrogen.

Reactions

A characteristic reaction is with amines to give methyl thioureas:
CH₃NCS + R₂NH → R₂NC(S)NHCH₃
Other nucleophiles add similarly.

Aroma threshold values

Very high strength odor; recommend smelling in a 0.01% solution or less

General Description

A colorless liquid with a sharp odor. Lethal by inhalation of even small quantities of vapor. Does not have odor warning characteristics at low concentrations. Do not rely on the sense of smell to warn about the presence of vapors. Denser than water. Flash point below 20°F. May cause tearing and irritate the eyes, skin, nose and throat.

Air & Water Reactions

Highly flammable. Methyl isothiocyanate reacts with water to form carbon dioxide and methylamine gases.

Reactivity Profile

Isocyanates and thioisocyanates, such as Methyl isothiocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol.

Hazard

Toxic by ingestion, strong irritant to eyesand skin.

Health Hazard

Very toxic; probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 lb.) person. Highly irritating to skin, mucous membrances, and eyes. Human oral minimum lethal dose: approximately 1 g/kg.

Fire Hazard

(Non-Specific -- Pesticide, Solid, n.o.s.) Methyl isothiocyanate may burn, but does not ignite readily. Fire may produce irritating or poisonous gases. When heated Methyl isothiocyanate emits very dangerous cyanides and sulfur compounds. Do not store below -4F or at elevated temperatures. Keep away from sparks.

Safety

MITC is a dangerous lachrymator as well as being poisonous.

Chemical Synthesis

It is prepared industrially by two routes. Annual production in 1993 was estimated to be 4M kg. The main method involves the thermal rearrangement of methyl thio cyanate :
CH₃S - C ≡ N → CH₃N = C = S
It is also prepared via with the reaction of methylamine with carbon disulfide followed by oxidation of the resulting dithio carbamate with hydrogen peroxide. A related method is useful to prepare this compound in the laboratory.
MITC forms naturally upon the enzymatic degradation of gluco capparin , a modified sugar found in capers.

Potential Exposure

It is used as a soil fumigant. A mixture of methyl isothiocyanate and chlorinated C-3 hydrocarbons is used as a soil fumigant for control of weeds, fungi, insects, and nematodes.

Environmental Fate

Soil. Though no products were reported, the reported half-life in soil is <14 days (Worthing and Hance, 1991).
Chemical/Physical. Emits toxic fumes of nitrogen and sulfur oxides when heated to decomposition (Sax and Lewis, 1987).

Metabolic pathway

Methyl isothiocyanate is slowly decomposed in pure water, forming methylamine. It is metabolised in rats to the mercapturate via the glutathione conjugate which serves as a potential source of methyl isothiocyanate. Methyl isothiocyanate is reactive with cellular thiols and amines and its toxicity is associated with these reactions.

Shipping

UN2477 Methyl isothiocyanate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, Inhalation Hazard Zone B.

Degradation

Methyl isothiocyanate is unstable and reactive. It is rapidly hydrolysed by alkalis but more slowly in acidic or neutral solutions. DT₅₀ values for hydrolysis were 85,490 and 110 hours at pH 5,7 and 9, respectively. It is sensitive to oxgen and to light (PM). The relatively slow hydrolysis of methyl isothiocyanate in pure water can be accelerated by adding high concentrations of acid. Thiocarbamic acid is formed that in turn decomposes rapidly to protonated methylamine. Addition of water to the isothiocyanate N=C bond via a mechanism involving synchronous nucleophilic attack at carbon and proton transfer to nitrogen with a cyclic transition state is proposed. Methyl isothiocyanate is 10⁷ times less susceptible to acid catalysis in water than its O-analogue (Joseph et al., 1992). It will also combine with various essential nucleophilic centres in biological systems. For example, it reacts with cysteine in vitro, forming a dithiocarbamate derivative in solutions of pH greater than 6 (Goksoyr, 1964).
The fungicide is photolysed in the gas phase with a half life of 10 hours under irradiation from a xenon arc lamp and slightly more than one day for late summer sunlight in Nevada, USA. The relatively rapid photolysis of methyl isothiocyanate had not previously been observed in other experiments in aqueous solutions where rates were 20 times slower. Products of photolysis were methyl isocyanide (2), sulfur dioxide, hydrogen sulfide, N-methylformamide (3), methylamine and carbonyl sulfide. Methyl isocyanide (2) was initially the main product and it yielded methyl isocyanate (4) (Geddes et al., 1995).

Toxicity evaluation

MITC stimulates chemesthesis, the activation of receptors associated with sensations of pain, touch, or thermal perception, through activation of transient receptor potential (TRPA1) ion channels. Isothiocyanate molecules have an electrophilic carbon atom that reacts with nucleophilic components, such as cysteine residues in the TRPA1 channels that are highly sensitive and serve as a warning mechanism to prevent tissue damage. MITC can form a reversible covalent bond with receptors to stimulate a reaction instead of acting directly through tissue damage. MITC is less potent than other isothiocyanates, such as allyl isothiocyanate (i.e., the active component of horseradish, wasabi, and mustard). At low concentrations, endogenous nucleophiles (e.g., GSH) may neutralize the electrophilic carbon and, therefore, prevent damage, but as concentrations increase their effectiveness decreases. Although the mode of action of MITC for systemic toxicity is not known, MITC is proposed to react with, and inactivate, the sulfhydryl group of essential enzymes in living organisms.

Incompatibilities

Dust may form explosive mixture with air. Reacts with water, releasing carbon dioxide and methylamine gases. Unstable and reactive; sensitive to oxygen and to light. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, strong bases, amines, water, heat and cold. Attacks iron, zinc and other metals

Waste Disposal

In accordance with 40CFR 165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

Methyl isothiocyanate(556-61-6)Related Product Information

• PHENYL ISOTHIOCYANATE
• CYCLOHEXANEMETHYL ISOTHIOCYANATE
• Isopropyl isothiocyanate
• CYCLOPENTYL ISOTHIOCYANATE
• Ethyl isocyanoacetate
• Fluorescein isothiocyanate isomer I
• Guanidine thiocyanate
• PROPYL ISOTHIOCYANATE
• 4-BROMOPHENYL ISOTHIOCYANATE
• BENZYL ISOTHIOCYANATE
• ISOBUTYL ISOTHIOCYANATE
• BUTYL ISOTHIOCYANATE
• m-Tolyl isocyanate
• Propyl isocyanate
• 2-FLUORO-5-METHYLPHENYL ISOCYANATE
• 3-Isocyanatopropyltriethoxysilane
• Kresoxim-methyl
• Methyl acrylate