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Methyl isothiocyanate

Product Name
Methyl isothiocyanate
CAS No.
556-61-6
Chemical Name
Methyl isothiocyanate
Synonyms
MIT;isothiocyanatomethane;MIC;MENCS;CH3NCS;MITC;MTC;TRK;TRKA;NTRK1
CBNumber
CB6455336
Molecular Formula
C2H3NS
Formula Weight
73.12
MOL File
556-61-6.mol
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Methyl isothiocyanate Property

Melting point:
30-34 °C(lit.)
Boiling point:
117-118 °C(lit.)
Density 
1.069 g/mL at 25 °C(lit.)
vapor pressure 
21 mm Hg ( 20 °C)
refractive index 
nD37 1.5258
FEMA 
4426 | METHYL ISOTHIOCYANATE
Flash point:
90 °F
storage temp. 
2-8°C
solubility 
H2O: slightly soluble
form 
Low Melting Solid
color 
White to pale yellow
Odor
at 0.01 % in propylene glycol. pungent mustard horseradish
Odor Type
pungent
Water Solubility 
7.6 g/L
Sensitive 
Moisture Sensitive
Merck 
14,6092
JECFA Number
1884
BRN 
605319
Stability:
Stable. Incompatible with strong oxidizing agents, alcohols, strong bases, amines.
InChIKey
LGDSHSYDSCRFAB-UHFFFAOYSA-N
LogP
1.3 at 20℃
CAS DataBase Reference
556-61-6(CAS DataBase Reference)
NIST Chemistry Reference
Methane, isothiocyanato-(556-61-6)
EPA Substance Registry System
Methyl isothiocyanate (556-61-6)
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Safety

Hazard Codes 
T,N
Risk Statements 
23/25-34-43-50/53
Safety Statements 
36/37-38-45-60-61
RIDADR 
UN 2477 6.1/PG 1
WGK Germany 
3
RTECS 
PA9625000
21
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
I
HS Code 
29309090
Hazardous Substances Data
556-61-6(Hazardous Substances Data)
Toxicity
LD50 in rats, mice (mg/kg): 220, 110 orally; in rabbits (mg/kg): 33 dermally (Vernot); LD50 s.c. in mice: 0.05 g/kg (Klesse, Lukoschek)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
112771
Product name
Methyl isothiocyanate
Purity
97%
Packaging
5g
Price
$28.6
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB1305365
Product name
ANTI-TRKA (CENTER) antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
400μL
Price
$481
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB1305087
Product name
ANTI-PHOSPHO-TRKA(Y791) antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
400μL
Price
$481
Updated
2024/03/01
Sigma-Aldrich
Product number
112771
Product name
Methyl isothiocyanate
Purity
97%
Packaging
100g
Price
$112
Updated
2024/03/01
Alfa Aesar
Product number
A11757
Product name
Methyl isothiocyanate, 98%
Packaging
25g
Price
$34.2
Updated
2024/03/01
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Methyl isothiocyanate Chemical Properties,Usage,Production

Description

Methyl iso thio cyanate is the organo sulfur compound with the formula CH3N = C = S . This low melting colorless solid is a powerful lachrymator. As a precursor to a variety of valuable bioactive compounds, it is the most important organic iso thio cyanate in industry.

Chemical Properties

Colorless to tan liquid; pungent, penetrating, mustard-like odor.

Chemical Properties

colourless solid

Chemical Properties

Methyl isothiocyanate is a crystalline solid. Horseradish, acrid odor.

Occurrence

Reported found in horseradish.

Uses

Pesticide; soil fumigant.

Uses

Usually used to study the effect of pesticide Metam (methyl isothiocyanate is its active ingredient) in the streamside microbial communities of the upper Sacramento river

Uses

Pesticide and soil fumigant used to control insects, soil fungi, nematodes.

Application

Solutions of MITC are used in agriculture as soil fumigants, mainly for protection against fungi and nematodes.
MITC is a building block for the synthesis of 1,3,4 - thiadiazoles, which are heterocyclic compounds used as herbicides. Commercial products include "Spike", "Ustilan," and "Erbotan." Well known pharmaceuticals prepared using MITC include Zantac and Tagamet.

Definition

ChEBI: An isothiocyanate having a methyl group attached to the nitrogen.

Reactions

A characteristic reaction is with amines to give methyl thioureas:
CH3NCS + R2NH → R2NC(S)NHCH3
Other nucleophiles add similarly.

Aroma threshold values

Very high strength odor; recommend smelling in a 0.01% solution or less

General Description

A colorless liquid with a sharp odor. Lethal by inhalation of even small quantities of vapor. Does not have odor warning characteristics at low concentrations. Do not rely on the sense of smell to warn about the presence of vapors. Denser than water. Flash point below 20°F. May cause tearing and irritate the eyes, skin, nose and throat.

Air & Water Reactions

Highly flammable. Methyl isothiocyanate reacts with water to form carbon dioxide and methylamine gases.

Reactivity Profile

Isocyanates and thioisocyanates, such as Methyl isothiocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol.

Hazard

Toxic by ingestion, strong irritant to eyesand skin.

Health Hazard

Very toxic; probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 lb.) person. Highly irritating to skin, mucous membrances, and eyes. Human oral minimum lethal dose: approximately 1 g/kg.

Fire Hazard

(Non-Specific -- Pesticide, Solid, n.o.s.) Methyl isothiocyanate may burn, but does not ignite readily. Fire may produce irritating or poisonous gases. When heated Methyl isothiocyanate emits very dangerous cyanides and sulfur compounds. Do not store below -4F or at elevated temperatures. Keep away from sparks.

Flammability and Explosibility

Non flammable

Safety

MITC is a dangerous lachrymator as well as being poisonous.

Synthesis

It is prepared industrially by two routes. Annual production in 1993 was estimated to be 4M kg. The main method involves the thermal rearrangement of methyl thio cyanate :
CH3S - C ≡ N → CH3N = C = S
It is also prepared via with the reaction of methylamine with carbon disulfide followed by oxidation of the resulting dithio carbamate with hydrogen peroxide. A related method is useful to prepare this compound in the laboratory.
MITC forms naturally upon the enzymatic degradation of gluco capparin , a modified sugar found in capers.

Potential Exposure

It is used as a soil fumigant. A mixture of methyl isothiocyanate and chlorinated C-3 hydrocarbons is used as a soil fumigant for control of weeds, fungi, insects, and nematodes.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at leastFirst Aid: If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifing upper and lower lids. Seek med-ical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, includ-ing resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medi-cal attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.Medical observation is recommended for 24- -48 h afterbreathing overexposure, as pulmonary edema may bedelayed. As first aid for pulmonary edema, a doctor orauthorized paramedic may consider administering a cortico-steroid spray.

Environmental Fate

Soil. Though no products were reported, the reported half-life in soil is <14 days (Worthing and Hance, 1991).
Chemical/Physical. Emits toxic fumes of nitrogen and sulfur oxides when heated to decomposition (Sax and Lewis, 1987).

Metabolic pathway

Methyl isothiocyanate is slowly decomposed in pure water, forming methylamine. It is metabolised in rats to the mercapturate via the glutathione conjugate which serves as a potential source of methyl isothiocyanate. Methyl isothiocyanate is reactive with cellular thiols and amines and its toxicity is associated with these reactions.

storage

(1) Color Code—Red: Flammability Hazard: Storein a flammable liquid storage area or approved cabinetaway from ignition sources and corrosive and reactivematerials. (2) Color Code—Blue: Health Hazard/Poison:Store in a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area. Sources of ignition, such as smoking andopen flames, are prohibited where methyl isothiocyanate isused, handled, or stored in a manner that could create apotential fire or explosion hazard. Metal containers involving the transfer of 5 gallons or more of this chemical shouldbe grounded and bonded. Drums must be equipped withself-closing valves, pressure vacuum bungs, and flamearresters. Use only nonsparking tools and equipment, especially when opening and closing containers of this chemical. Wherever this chemical is used, handled, manufactured,or stored, use explosion-proof electrical equipment andfittings.

Shipping

UN2477 Methyl isothiocyanate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, Inhalation Hazard Zone B.

Degradation

Methyl isothiocyanate is unstable and reactive. It is rapidly hydrolysed by alkalis but more slowly in acidic or neutral solutions. DT50 values for hydrolysis were 85,490 and 110 hours at pH 5,7 and 9, respectively. It is sensitive to oxgen and to light (PM). The relatively slow hydrolysis of methyl isothiocyanate in pure water can be accelerated by adding high concentrations of acid. Thiocarbamic acid is formed that in turn decomposes rapidly to protonated methylamine. Addition of water to the isothiocyanate N=C bond via a mechanism involving synchronous nucleophilic attack at carbon and proton transfer to nitrogen with a cyclic transition state is proposed. Methyl isothiocyanate is 107 times less susceptible to acid catalysis in water than its O-analogue (Joseph et al., 1992). It will also combine with various essential nucleophilic centres in biological systems. For example, it reacts with cysteine in vitro, forming a dithiocarbamate derivative in solutions of pH greater than 6 (Goksoyr, 1964).
The fungicide is photolysed in the gas phase with a half life of 10 hours under irradiation from a xenon arc lamp and slightly more than one day for late summer sunlight in Nevada, USA. The relatively rapid photolysis of methyl isothiocyanate had not previously been observed in other experiments in aqueous solutions where rates were 20 times slower. Products of photolysis were methyl isocyanide (2), sulfur dioxide, hydrogen sulfide, N-methylformamide (3), methylamine and carbonyl sulfide. Methyl isocyanide (2) was initially the main product and it yielded methyl isocyanate (4) (Geddes et al., 1995).

Toxicity evaluation

MITC stimulates chemesthesis, the activation of receptors associated with sensations of pain, touch, or thermal perception, through activation of transient receptor potential (TRPA1) ion channels. Isothiocyanate molecules have an electrophilic carbon atom that reacts with nucleophilic components, such as cysteine residues in the TRPA1 channels that are highly sensitive and serve as a warning mechanism to prevent tissue damage. MITC can form a reversible covalent bond with receptors to stimulate a reaction instead of acting directly through tissue damage. MITC is less potent than other isothiocyanates, such as allyl isothiocyanate (i.e., the active component of horseradish, wasabi, and mustard). At low concentrations, endogenous nucleophiles (e.g., GSH) may neutralize the electrophilic carbon and, therefore, prevent damage, but as concentrations increase their effectiveness decreases. Although the mode of action of MITC for systemic toxicity is not known, MITC is proposed to react with, and inactivate, the sulfhydryl group of essential enzymes in living organisms.

Incompatibilities

Dust may form explosive mixture with air. Reacts with water, releasing carbon dioxide and methylamine gases. Unstable and reactive; sensitive to oxygen and to light. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, strong bases, amines, water, heat and cold. Attacks iron, zinc and other metals

Waste Disposal

In accordance with 40CFR 165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

Methyl isothiocyanate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl isothiocyanate Suppliers

Jikang Chemical Industry Co. , Ltd.
Tel
0573-85609002 18157336032
Email
zhejia01@163.com
Country
China
ProdList
7859
Advantage
58
TOSUN PHARM
Tel
020-61855200 13326451905
Email
260366801@qq.com
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China
ProdList
7774
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Weifang YuKai Chemical Co., Ltd.
Tel
536-0536-8865336 13853655610
Fax
86-536-5310398
Email
sophia@kaihongchem.com
Country
China
ProdList
41
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
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China
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44689
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Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
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4000311741
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master@sjzsdyn.com
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China
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Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
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+86-10-82967029
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Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
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info@hanhongsci.com
Country
China
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View Lastest Price from Methyl isothiocyanate manufacturers

Qiuxian Baitai New Material Co., LTD
Product
MIT
Price
US $52.00-24.00/mg
Min. Order
1kit
Purity
99%
Supply Ability
500000 vial/Month
Release date
2021-07-21
Qiuxian Baitai New Material Co., LTD
Product
MIT
Price
US $40.00/mg
Min. Order
10mg
Purity
99%
Supply Ability
5ton/Month
Release date
2021-10-18
Career Henan Chemical Co
Product
Methyl isothiocyanate 556-61-6
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

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