5-ISOTHIAZOLECARBOXYLIC ACID
- Product Name
- 5-ISOTHIAZOLECARBOXYLIC ACID
- CAS No.
- 10271-85-9
- Chemical Name
- 5-ISOTHIAZOLECARBOXYLIC ACID
- Synonyms
- 5-ISOTHIAZOLECARBOXYLIC ACID;ISOTHIAZOLE-5-CARBOXYLIC ACID;1,2-thiazole-5-carboxylic acid;8-Isoquinoline-methaneaminedihydrochloride
- CBNumber
- CB2317896
- Molecular Formula
- C4H3NO2S
- Formula Weight
- 129.14
- MOL File
- 10271-85-9.mol
5-ISOTHIAZOLECARBOXYLIC ACID Property
- Melting point:
- 196-200℃ (decomposition)
- Boiling point:
- 178.4±23.0℃ (760 Torr)
- Density
- 1.525±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 61.7±22.6℃
- storage temp.
- 2-8°C
- form
- Solid
- pka
- 1.23±0.10(Predicted)
- color
- Off-white to light brown
Safety
- HS Code
- 2934208090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- I917608
- Product name
- Isothiazole-5-carboxylicacid
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 280318
- Product name
- Isothiazole-5-carboxylic acid
- Packaging
- 100mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- OR313078
- Product name
- Isothiazole-5-carboxylic acid
- Packaging
- 250mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- 0659AA
- Product name
- Isothiazole-5-carboxylicacid
- Packaging
- 1g
- Price
- $266
- Updated
- 2021/12/16
- Product number
- OR313078
- Product name
- Isothiazole-5-carboxylic acid
- Packaging
- 1g
- Price
- $513
- Updated
- 2021/12/16
5-ISOTHIAZOLECARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
Isothiazole-5-carboxylic acid (8-Isoquinoline-methaneaminedihydrochloride) is an organic compound with antibacterial, anticancer and anti-inflammatory properties. Isothiazole-5-carboxylic acid can be used to develop novel compounds to combat various diseases. Isothiazole-5-carboxylic acid exhibits a wide range of potential pharmacological activities and helps improve existing inhibitory schemes.
Synthesis
15901-66-3
10271-85-9
Methyl isothiazole-5-carboxylate (0.50 g, 3.49 mmol) was dissolved in a THF/MeOH solvent mixture (20 mL/5 mL) at room temperature, followed by slow addition of 1N NaOH solution (5.24 mL, 5.24 mmol). The reaction mixture was stirred continuously for 16 h at room temperature and the completion of the reaction was confirmed by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the reaction mixture was acidified to pH 2 with 1N HCl solution, at which point a precipitate was observed to be generated. The precipitate was separated by filtration and dried to afford the target product isothiazole-5-carboxylic acid (Compound 2) as a beige solid in a yield of 0.35 g (76% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-d6) with chemical shifts of δ 8.69 (d, 1H) and 7.85 (d, 1H), respectively.
References
[1] Patent: US2007/105864, 2007, A1. Location in patent: Page/Page column 151-152
[2] Patent: US2007/117804, 2007, A1. Location in patent: Page/Page column 78
5-ISOTHIAZOLECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-ISOTHIAZOLECARBOXYLIC ACID manufacturers
- Product
- 5-ISOTHIAZOLECARBOXYLIC ACID 10271-85-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03