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Ethoxycarbonyl Isothiocyanate

Product Name
Ethoxycarbonyl Isothiocyanate
CAS No.
16182-04-0
Chemical Name
Ethoxycarbonyl Isothiocyanate
Synonyms
O-ethyl carbonisothiocyanatidate;ethyl N-carbothioylcarbamate;ETHYL ISOTHIOCYANATOFORMATE;Ethyl carbonisothiocyanatidate;NSC 158480;CARBETHOXYISOTHIOCYANATE;Ethoxycarbonyl Mustard Oil;ETHOXYCARBONYL ISOTHIOCYANATE;ETHYL ISOTHIOCYANATOFORMATE,98%;Ethyl isothiocyanatidocarbonate
CBNumber
CB1265381
Molecular Formula
C4H5NO2S
Formula Weight
131.15
MOL File
16182-04-0.mol
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Ethoxycarbonyl Isothiocyanate Property

Boiling point:
56 °C18 mm Hg(lit.)
Density 
1.112 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.500(lit.)
Flash point:
123 °F
storage temp. 
2-8°C
solubility 
Soluble in chloroform and ether.
form 
Oil
Specific Gravity
1.112
color 
Light Yellow
Sensitive 
Moisture Sensitive/Lachrymatory
BRN 
606091
InChIKey
BDTDECDAHYOJRO-UHFFFAOYSA-N
CAS DataBase Reference
16182-04-0(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
23-36/37/38-42
Safety Statements 
23-26-36/37/39-45
RIDADR 
UN 2929 6.1/PG 2
WGK Germany 
3
9-13-19-21
HazardClass 
3
PackingGroup 
III
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H331Toxic if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
196126
Product name
Ethoxycarbonyl isothiocyanate
Purity
98%
Packaging
5g
Price
$89.6
Updated
2024/03/01
Sigma-Aldrich
Product number
196126
Product name
Ethoxycarbonyl isothiocyanate
Purity
98%
Packaging
25g
Price
$260
Updated
2024/03/01
TCI Chemical
Product number
E0440
Product name
Ethoxycarbonyl Isothiocyanate
Purity
>95.0%(GC)
Packaging
5g
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
E0440
Product name
Ethoxycarbonyl Isothiocyanate
Purity
>95.0%(GC)
Packaging
25g
Price
$88
Updated
2024/03/01
Alfa Aesar
Product number
L00911
Product name
Ethoxycarbonyl isothiocyanate, 97%
Packaging
5g
Price
$63.65
Updated
2024/03/01
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Ethoxycarbonyl Isothiocyanate Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Oil

Uses

Versatile reagent for organic synthesis.
Ethoxycarbonyl isothiocyanate is used as a building block in the synthesis of various heterocycles. It is also used for the synthesis of 1,2,4-oxadiazolidine-3,5-dione. It is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Uses

Ethoxycarbonyl isothiocyanate has been used in the synthesis of:

  • pyrazolo[1,5-a][1,3,5]triazine derivatives, potential inhibitors of protein kinase CK2
  • fused thiophene derivatives, having antibacterial and antifungal activities
  • 4-thiouracil derivatives
  • thiocarbamides from stannylarenes
  • 1,3,5-triazin-2-one-4-thiones from 2-amino-2-oxazolines
  • N-acylthioureas from aminodeoxy sugars

Application

Ethoxycarbonyl isothiocyanate reacts with 2-amino-tetrahydrobenzo[b]thiophene derivatives to yield tetrahydrobenzo[b]thiophen-2-thiourea derivatives.
Ethoxycarbonyl isothiocyanate has been used in the synthesis of:
pyrazolo[1,5-a][1,3,5]triazine derivatives, potential inhibitors of protein kinase CK2
fused thiophene derivatives, having antibacterial and antifungal activities
4-thiouracil derivatives
thiocarbamides from stannylarenes
1,3,5-triazin-2-one-4-thiones from 2-amino-2-oxazolines
N-acylthioureas from aminodeoxy sugars

Synthesis Reference(s)

Using Schiff base as a phase transfer catalyst, ethoxycarbonyl isothiocyanate was synthesized by reacting ethyl chloroformate with sodium thiocyanate. www.semanticscholar.org

General Description

Ethoxycarbonyl isothiocyanate reacts with 2-amino-tetrahydrobenzo[b]thiophene derivatives to yield tetrahydrobenzo[b]thiophen-2-thiourea derivatives.

Hazard

Lachrymator.

Ethoxycarbonyl Isothiocyanate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethoxycarbonyl Isothiocyanate Suppliers

Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1542
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
021-50430803 18017383231
Fax
qq:2817624287
Email
983544897@qq.com
Country
China
ProdList
9352
Advantage
55
Zhejiang Sachem Pharmaceutical Technology Co., Ltd.
Tel
0571-15397178950 15397178950
Email
jacky@sachenpharm.com
Country
China
ProdList
363
Advantage
58
Suzhou Guide Fine Material Co., Ltd.
Tel
512-68236360 13912645265
Email
lxm@guide-chemicals.com
Country
China
ProdList
235
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
sales@zhiwe.net
Country
China
ProdList
579
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
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View Lastest Price from Ethoxycarbonyl Isothiocyanate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ethoxycarbonyl isothiocyanate 16182-04-0
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-19
Hebei Mojin Biotechnology Co., Ltd
Product
Ethoxycarbonyl Isothiocyanate 16182-04-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-15
Hebei Guanlang Biotechnology Co., Ltd.
Product
Ethoxycarbonyl Isothiocyanate 16182-04-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2021-11-15

16182-04-0, Ethoxycarbonyl IsothiocyanateRelated Search:


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