4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

Product Name: 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE
CAS No.: 54346-19-9
Chemical Name: 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE
Synonyms: 5-a][1;pyrazolo[1,5-a][1,3,5]triazine;4-chloro-2-(Methylthio)pyrazolo[1;4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE;Pyrazolo[1,5-a]-1,3,5-triazine, 4-chloro-2-(methylthio)-;4-Chloro-2-methylsulfanyl-pyrazolo[1,5-a][1,3,5]triazine;4-chloro-2-(methylthio)-1,2-dihydropyrazolo[1,5-a][1,3,5]triazine
CBNumber: CB8494476
Molecular Formula: C6H5ClN4S
Formula Weight: 200.65
MOL File: 54346-19-9.mol

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4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Property

Density: 1.67±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.84±0.30(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C994618
Product name: 4-Chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine
Packaging: 50mg
Price: $110
Updated: 2021/12/16

TRC

Product number: C994618
Product name: 4-Chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine
Packaging: 100mg
Price: $175
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC148867
Product name: 4-Chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine
Packaging: 100mg
Price: $136
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC148867
Product name: 4-Chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine
Packaging: 250mg
Price: $270
Updated: 2021/12/16

AK Scientific

Product number: W6859
Product name: 4-Chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine
Packaging: 250mg
Price: $382
Updated: 2021/12/16

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4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Chemical Properties,Usage,Production

Synthesis

54346-18-8

54346-19-9

The general procedure for the synthesis of 4-chloro-2-(methylthio)pyrazolo[1,5-alpha][1,3,5]triazin-4(3H)-one from 2-(methylthio)pyrazolo[1,5-α][1,3,5]triazin-4(3H)-one was as follows: to a stirred suspension of 2-(methylthio)pyrazolo[1,5-alpha][1,3,5]triazin-4(3H)-one (2.0 g. 11 mmol) and a suspension of trichlorophosphorus (20 mL) was added to N,N-diethylaniline (0.7 mL). The reaction mixture was heated to reflux temperature. After 1.5 hours of reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in toluene and the organic layer was washed with brine and concentrated again under reduced pressure to give 4-chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine (2.0 g, 91% yield).TLC Rf = 0.57 (ethyl acetate/hexane, 1/3); 1H NMR (300 MHz, CDCl3) δ 8.15 (d, J = 2.2Hz , 1H), 6.50 (d, J = 2.2 Hz, 1H), 2.60 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 20, p. 5955 - 5966
[2] Patent: US2007/78136, 2007, A1. Location in patent: Page/Page column 50
[3] Patent: WO2011/31979, 2011, A1. Location in patent: Page/Page column 147
[4] Patent: US9303033, 2016, B2. Location in patent: Page/Page column 285; 286
[5] Patent: JP5802676, 2015, B2. Location in patent: Paragraph 0552

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Preparation Products And Raw materials

Raw materials

Ethoxycarbonyl Isothiocyanate 3-Aminopyrazole Ethanol Phosphorus oxitrichloride N,N-Dimethylaniline Benzene Ethyl acetate Sodium hydroxide Iodomethane Sulfuric acid

Preparation Products

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4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Suppliers

China 74 Germany 2 India 3 United Kingdom 1 United States 11 Global 91

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View Lastest Price from 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE manufacturers

Career Henan Chemical Co

Product: 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE 54346-19-9
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

Career Henan Chemical Co

Product: 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE 54346-19-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-08

54346-19-9, 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINERelated Search:

8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

4-Chloro-2-methylsulfanyl-pyrazolo[1,5-a][1,3,5]triazine

4-chloro-2-(Methylthio)pyrazolo[1

5-a][1

4-chloro-2-(methylthio)-1,2-dihydropyrazolo[1,5-a][1,3,5]triazine

pyrazolo[1,5-a][1,3,5]triazine

Pyrazolo[1,5-a]-1,3,5-triazine, 4-chloro-2-(methylthio)-

54346-19-9

C6H5ClN4S

CHIRAL CHEMICALS