ChemicalBook > Product Catalog > Biochemical Engineering > Amino Acids and Derivatives > Aspartic acid derivatives > 2-AMINO-2-METHYLSUCCINIC ACID
2-AMINO-2-METHYLSUCCINIC ACID
2-AMINO-2-METHYLSUCCINIC ACID Basic information
- Product Name:
- 2-AMINO-2-METHYLSUCCINIC ACID
- Synonyms:
-
- ALPHA-METHYL-DL-ASPARTIC ACID
- 2-AMINO-2-METHYLSUCCINIC ACID
- A-methyl-dl-aspartic acid
- DL-ALPHA-METHYLASPARTIC ACID
- Aspartic acid, 2-methyl-
- α-Me-DL-Asp-OH
- 2-amino-2-methylbutanedioicaci
- 2-AMINO-2-METHYLSUCCINIC ACID USP/EP/BP
- CAS:
- 2792-66-7
- MF:
- C5H9NO4
- MW:
- 147.13
- Mol File:
- 2792-66-7.mol
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2-AMINO-2-METHYLSUCCINIC ACID Chemical Properties
- Melting point:
- 234-237 °C (decomp)
- Boiling point:
- 259.2±30.0 °C(Predicted)
- Density
- 1.414±0.06 g/cm3(Predicted)
- pka
- 2.32±0.28(Predicted)
- form
- Solid
- color
- White to off-white
- CAS DataBase Reference
- 2792-66-7
MSDS
- Language:English Provider:SigmaAldrich
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2-AMINO-2-METHYLSUCCINIC ACID Usage And Synthesis
Uses
α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine[1].
in vivo
α-methyl-dl-aspartic acid (147 mg/kg, i.v.) can diminish the l-citrulline-induced retinal vasodilation in Wistar rats[1].
| Animal Model: | Wistar rats |
| Dosage: | 147 mg/kg |
| Administration: | 147 mg/kg, i.v. |
| Result: | Attenuated the increase of retinal arteriolar diameter induced by L-citrulline. |
References
[1] Asami Mori, et al. l-Citrulline dilates rat retinal arterioles via nitric oxide- and prostaglandin-dependent pathways in vivo. J Pharmacol Sci. 2015 Apr;127(4):419-23. DOI:10.1016/j.jphs.2015.02.012
[2] Juliano R Guerreiro, et al. Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production. J Biol Chem. 2009 Jul 24;284(30):20022-33. DOI:10.1074/jbc.M109.021089
2-AMINO-2-METHYLSUCCINIC ACIDSupplier
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2-AMINO-2-METHYLSUCCINIC ACID(2792-66-7)Related Product Information
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- bis(3,5-dimethyl-5-hydroxymethyl-2-oxomorpholin-3-yl)
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