BI605906 Chemical Properties

Boiling point:

713.7±60.0 °C(Predicted)

Density 

1.48±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Acetonitrile: 1 mg/ml; DMSO: 30 mg/ml

form 

A crystalline solid

pka

16.18±0.30(Predicted)

color 

Light yellow to yellow

InChI

1S/C17H22F2N4O3S2/c1-3-17(18,19)10-8-11(23-6-4-9(5-7-23)28(2,25)26)22-16-12(10)13(20)14(27-16)15(21)24/h8-9H,3-7,20H2,1-2H3,(H2,21,24)

InChIKey

IYHHRZBKXXKDDY-UHFFFAOYSA-N

SMILES

CCC(F)(C1=C2C(SC(C(N)=O)=C2N)=NC(N3CCC(CC3)S(C)(=O)=O)=C1)F

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

BI605906 Usage And Synthesis

Uses

BI 605906, is a novel inhibitors of the kappa B kinase subunit β (IKKβ; IC50 = 380 nM).

Biological Activity

BI605906 is a selective, ATP-competitive IKB kinase β (IKK2, IKKβ, IKK-beta) inhibitor (IC50 = 380 nM, [ATP] = 0.1 mM) with no potency toward 100 other kinases, including IKKα, IKKε, TBK1, and IGF1R (IC50 ≥7.6 μM). BI605906 (10 μM) effectively blocks IKK-β-dependent phosphorylation of IKKε and TBK1 in IKKα-/- MEFs upon IL-1α (5 ng/mL) induction.

IC 50

IKKβ: 380 nM (IC₅₀, at 0.1 mM ATP)

storage

Store at -20°C