Rolapitant
Rolapitant Basic information
- Product Name:
- Rolapitant
- Synonyms:
-
- Rolapitant
- (5S,8S)-8-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one hydrochloride.
- Rolapitant HCl
- Rolapitant(sch619734)
- (5S,8S)-8-[[[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl]oxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one
- (5S,8S)-8-({(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one
- rolapitant,914462-92-3
- 1,7-Diazaspiro[4.5]decan-2-one,8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-,(5S,8S)-
- CAS:
- 552292-08-7
- MF:
- C25H26F6N2O2
- MW:
- 500.48
- EINECS:
- 812-147-5
- Mol File:
- 552292-08-7.mol
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Rolapitant Chemical Properties
- Boiling point:
- 523.5±50.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 16 mg/ml; Ethanol: 3 mg/ml
- pka
- 15.88±0.40(Predicted)
- form
- Powder
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Rolapitant Usage And Synthesis
Definition
ChEBI: An azaspiro compound that is 1,7-diazaspiro[4.5]decan-2-one carrying additional phenyl and 1-{[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl substituents at position 8. Used (in the form of the hydrochloride hydrate) for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.
RolapitantSupplier
Doly Chemical CO.,LTD. Gold
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Wuhan Topule Gold
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Hubei Kele Fine Chemical Co., Ltd Gold
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Shanghai Boyle Chemical Co., Ltd.
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Chemvon Biotechnology Co., Ltd
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