ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > PCI 29732
PCI 29732
PCI 29732 Basic information
- Product Name:
- PCI 29732
- Synonyms:
-
- PCI 29732
- 4-Amino-1-cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine
- 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- PCI 29732 (This product is only available in Japan.)
- CS-2698
- PCI 29732;PCI29732;PCI-29732
- 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-cyclopentyl-3-(4-phenoxyphenyl)-
- cytotoxicity,Bruton tyrosine kinase,Inhibitor,Btk,ABCG2,reversible,PCI 29732,BCR,inhibit,B-cell,BCRP,oral,Breast cancer resistance protein
- CAS:
- 330786-25-9
- MF:
- C22H21N5O
- MW:
- 371.43
- Mol File:
- 330786-25-9.mol
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PCI 29732 Chemical Properties
- Boiling point:
- 599.6±50.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
- pka
- 4.24±0.30(Predicted)
- form
- Powder
- color
- White to off-white
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PCI 29732 Usage And Synthesis
Uses
PCI 29732 (cas# 330786-25-9) is a useful research chemical. It is a COVID19-related research product.
Definition
ChEBI: 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an aromatic ether.
in vivo
PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP-binding site of ABCG2 and enhances the anti-tumor efficacy of substrate chemotherapeutic agents[2].
PCI 29732 (20 mg/kg; p.o.; every 3 d × 5 times) enhances the anticancer efficacy of Topotecan in the H460/MX20 cell xenograft nude mice model[2].
| Animal Model: | 5-6 weeks old athymic nude mice (bearing H460/MX20 cells)[2] |
| Dosage: | 20 mg/kg (combination with Topotecan; every 3 d × 5 times, i.p., 3 mg/kg; topotecan was given 1 h after PCI29732 administration) |
| Administration: | P.o.; every 3 d × 5 times |
| Result: | Significant reductions in tumor weight and volume were observed in the group treated with PCI29732 in combination with Topotecan. |
storage
Store at +4°C
PCI 29732Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
TOKYO CHEMICAL INDUSTRY CO., LTD.
- Tel
- 03-36680489
- Sales-JP@TCIchemicals.com
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
- Tel
- 13816107857
- sales@fortunechem-sh.com