c-GpAp Chemical Properties

Boiling point:

1159.9±75.0 °C(Predicted)

Density 

2.61±0.1 g/cm3(Predicted)

storage temp. 

-20°C

form 

powder

pka

0.96±0.70(Predicted)

color 

white to beige

Water Solubility 

Water : 20 mg/mL (29.66 mM)

InChIKey

RFCBNSCSPXMEBK-VBLLSAMJNA-N

SMILES

c1nc(N)c2nc[n]([C@H]3[C@@H](O)[C@@H]4OP(O)(=O)OC[C@@H]5O[C@@H]([n]6cnc7C(=O)N=C(N)Nc67)[C@@H](O)[C@@H]5OP(O)(=O)OC[C@@H]4O3)c2n1 |&1:8,9,11,18,20,32,34,41,r|

c-GpAp Usage And Synthesis

Uses

cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.

Uses

c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA.

Definition

ChEBI: C-GMP-AMP is a cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages. It is an adenyl ribonucleotide, a cyclic purine dinucleotide and a guanyl ribonucleotide. It is a conjugate acid of a c-GMP-AMP(2-).

Biochem/physiol Actions

cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.

in vivo

storage

+4°C