PNU-159682
PNU-159682 Basic information
- Product Name:
- PNU-159682
- Synonyms:
-
- PNU-159682
- PNU-159682 >95%
- (8S,10S)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-5,12-naphthacenedione
- PNU-159682 95%
- 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-, (8S,10S)-
- 5-hydroxy-6-tert.-butyl-1,1-pentamethylene-3,3-dimethyl-indane
- inhibit,non-Hodgkin’s lymphoma,PNU159682,ADCs Toxin,PNU-159682,acute myeloid leukemia,ADC Payload,EDV nanocell,AML,Inhibitor,ADC Cytotoxin,PNU 159682,Topoisomerase,NMS249,NHL
- (8S,10S)-6,8,11-Trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-(((1S,3R,4aS,9S,9aR,10aS)-9-methoxy-1-methyloctahydro-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl)oxy)-7,8,9,10-tetrahydrotetracene-5,12-dione
- CAS:
- 202350-68-3
- MF:
- C32H35NO13
- MW:
- 641.62
- Mol File:
- 202350-68-3.mol
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PNU-159682 Chemical Properties
- Boiling point:
- 838.5±65.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO: 2mg/mL, clear
- form
- Solid
- pka
- 7.34±0.60(Predicted)
- color
- Reddish Brown to red
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PNU-159682 Usage And Synthesis
Characteristics
PNU-159682, a metabolite of the anthracycline neomycin metabolite, is a DNA topoisomerase I (TopoI) inhibitor with excellent cytotoxicity. It is a more potent and tolerable ADC cytotoxin than doxorubicin in ADC synthesis.
Uses
PNU-159682 can be used in EDV nanocell technology to overcome drug resistance.
Biological Activity
PNU-159682, an active nemorubicin metabolite, is a highly potent anthracycline toxin th at retains antitumor activity in vivo. Similarly to other anthracyclines PNU-159682 intercalates between the CG base pairs of DNA, but the stability of the complexes is much higher.
PNU-159682Supplier
WuYan Pharmaceutical Technology (Shanghai) Co., Ltd. Gold
- Tel
- 021-61001086 13671938079
- sales@wuyanpharm.com
Levena (Suzhou) Biopharma Co., Ltd. Gold
- Tel
- 0512-81877925 051281877925
- info@levena.cn
Shanghai ruichang pharmaceutical technology co., LTD Gold
- Tel
- 18621054990
- maychemicals@sina.com
Wuhan Topule Gold
- Tel
- +86-02787215551 +86-19945035818
- 2936752263@qq.com
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. Gold
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com