ESI 09
ESI 09 Basic information
- Product Name:
- ESI 09
- Synonyms:
-
- α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
- ESI 09
- ESI09
- ESI-09
- (E)-3-(5-tert-butylisoxazol-3-yl)-2-(2-(3-chlorophenyl)hydrazono)-3-oxopropanenitrile
- α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile
- alpha-[(3-Chlorophenyl)hydrazono]-5-(1,1-dimethylethyl)-beta-oxo-3-isoxazolepropanenitrile
- 3-Isoxazolepropanenitrile, α-[2-(3-chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-
- CAS:
- 263707-16-0
- MF:
- C16H15ClN4O2
- MW:
- 330.77
- Product Categories:
-
- Inhibitors
- Mol File:
- 263707-16-0.mol
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ESI 09 Chemical Properties
- Melting point:
- >175°C (dec.)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- , faint yellow to dark orange
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ESI 09 Usage And Synthesis
Uses
ESI 09 acts as an EPAC inhibitor, preventing EPAC-mediated insulin release form β-pancreatic cells. Selective control for EPAC over PKA and decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells.
Biochem/physiol Actions
ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP). ESI-09 inhibits EPAC1 and EPAC2 with IC50 values of 3.2 and 1.4 μM, respectively, with no activity against PKA at 25 μM. In pancreatic cell lines, the compound blocks phosphorylation of Akt and insulin secretion. ESI-09 inhibits migration of pancreatic cancer cell lines.
storage
Store at +4°C
ESI 09Supplier
Suzhou Unite pharmTech Co., Ltd , Gold
- Tel
- 792-3901125 13222993784
- sales@unite-pharm.com
Shanghai Aitixi Biotechnology Co., Ltd Gold
- Tel
- 18721763493 18721763493
- 2493172863@qq.com
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
AdooQ BioScience, LLC
- Tel
- +1 (866) 930-6790
- info@adooq.com