Basic information Safety Supplier Related

ESI 09

Basic information Safety Supplier Related

ESI 09 Basic information

Product Name:
ESI 09
Synonyms:
  • α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
  • ESI 09
  • ESI09
  • ESI-09
  • (E)-3-(5-tert-butylisoxazol-3-yl)-2-(2-(3-chlorophenyl)hydrazono)-3-oxopropanenitrile
  • α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile
  • alpha-[(3-Chlorophenyl)hydrazono]-5-(1,1-dimethylethyl)-beta-oxo-3-isoxazolepropanenitrile
  • 3-Isoxazolepropanenitrile, α-[2-(3-chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-
CAS:
263707-16-0
MF:
C16H15ClN4O2
MW:
330.77
Product Categories:
  • Inhibitors
Mol File:
263707-16-0.mol
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ESI 09 Chemical Properties

Melting point:
>175°C (dec.)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
, faint yellow to dark orange
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Safety Information

WGK Germany 
3
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ESI 09 Usage And Synthesis

Uses

ESI 09 acts as an EPAC inhibitor, preventing EPAC-mediated insulin release form β-pancreatic cells. Selective control for EPAC over PKA and decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells.

Biochem/physiol Actions

ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP). ESI-09 inhibits EPAC1 and EPAC2 with IC50 values of 3.2 and 1.4 μM, respectively, with no activity against PKA at 25 μM. In pancreatic cell lines, the compound blocks phosphorylation of Akt and insulin secretion. ESI-09 inhibits migration of pancreatic cancer cell lines.

storage

Store at +4°C

ESI 09Supplier

Suzhou Unite pharmTech Co., Ltd , Gold
Tel
792-3901125 13222993784
Email
sales@unite-pharm.com
Shanghai Aitixi Biotechnology Co., Ltd Gold
Tel
18721763493 18721763493
Email
2493172863@qq.com
Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Email
info@adooq.com
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ESI 09(263707-16-0)Related Product Information