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Forskolin

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Forskolin Basic information

Product Name:
Forskolin
Synonyms:
  • 7BETA-ACETOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
  • 7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE
  • 7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-ENE-11-ONE
  • [3R-(3A,4AB,5B,6B,6AA,10A,10AB,10BA)]-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-6,10,10B-TRIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1H-NAPHTHO[2,1-B]PYRAN-1-ONE
  • 10a-beta,10b-alpha))-10-alph
  • 1-b)pyran-1-one,dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-1h-naphtho(
  • pentamethyl-6,10,10b-trihydroxy-,(3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,
  • FORSKOLIN FROM COLEUS FORSKOHLII
CAS:
66575-29-9
MF:
C22H34O7
MW:
410.5
EINECS:
266-410-9
Product Categories:
  • Signalling
  • Chiral Reagents
  • Neurochemicals
  • Intermediates & Fine Chemicals
  • Cyclic Nucleotide related
  • Heterocycles
  • Pharmaceuticals
  • CYCLOCORT
  • activator
  • Inhibitors
Mol File:
66575-29-9.mol
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Forskolin Chemical Properties

Melting point:
282-232 °C
alpha 
D25 -26.19° (c = 1.68 in CHCl3)
Boiling point:
520℃
Density 
1.23
refractive index 
1.5300 (estimate)
Flash point:
172℃
storage temp. 
room temp
solubility 
DMSO: 5 mg/mL stable at least 6 months at room temperature
pka
11.00±0.70(Predicted)
form 
powder
color 
off-white
Water Solubility 
Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water.
λmax
305nm(lit.)
Merck 
14,2476
BRN 
1692716
InChIKey
OHCQJHSOBUTRHG-KGGHGJDLSA-N
CAS DataBase Reference
66575-29-9
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Safety Information

Hazard Codes 
Xn
Risk Statements 
21
Safety Statements 
22-36/37
WGK Germany 
3
RTECS 
QL6150000
10-21
HS Code 
29329990

MSDS

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Forskolin Usage And Synthesis

Chemical Properties

Colorless Crystalline Solid

Uses

Forskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP.

Uses

glucocorticoid, antiinflammatory

Uses

adenylate cyclase activator, antiglaucoma, hypotensive, vasodilator

Uses

Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.[Cayman Chemical]

Uses

An adenylate cyclase activator and MAP kinase inhibitor

Uses

In purification of adenylate cyclase.

General Description

Forskolin, present predominantly in the root of Coleus forskohlii plant, is a potential pharmacological compound. It is used for treating hypertension, respiratory disorders and obesity. Forskolin is a diterpenoid capable of modulating adenylate cyclase enzyme and cyclic adenosine monophosphate (cAMP) levels. Engineering forskolin biosynthetic pathway caters its commercial production for pharmacological use. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. Forskolin promotes differentiation of hepatoma HepaRG cells and activates farnesoid X receptor (FXR) and pregnane X receptor(PXR).

Biological Activity

Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Also available as part of the PKA Tocriset™ .

Biochem/physiol Actions

Cell permeable: yes

Purification Methods

It is an antihypertensive, a positive ionotropic, a platelet aggregation inhibitor, and it has adenylate cyclase activating properties [Chem Abstr 89 244150 1978, de Souza et al. Med Res Rev 3 201 1983, X-ray: Tandon et al. Indian J Chem 15B 880 1977]. [Beilstein 18/5 V 55.]

ForskolinSupplier

Absin Bioscience Inc. Gold
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Shanghai TaoShu Biochemical Technology Co., Ltd. Gold
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021-33632979-
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Nanjing Spring & Autumn Biological Engineering Co., Ltd. Gold
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Nanjing Yuanzhi Biotechnology Co. Ltd. Gold
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025-66015785-
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MedBio?Pharmaceutical Technology Inc Gold
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021-69568360-
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order@med-bio.cn