Cbz-N-amido-PEG6-acid
Cbz-N-amido-PEG6-acid Basic information
- Product Name:
- Cbz-N-amido-PEG6-acid
- Synonyms:
-
- Cbz-N-amido-PEG6-acid
- CBZ-NH-PEG6-propionic acid
- CBZ-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid
- CBZ-NH-PEG6-CH2CH2COOH
- CBZ-N-AMIDO-PEG6-COOH
- CBZ-NH-PEG6-COOH
- Cbz-NH-PEG6-C2-acid
- 5,8,11,14,17,20-Hexaoxa-2-azatricosanedioic acid, 1-(phenylmethyl) ester
- CAS:
- 1334177-80-8
- MF:
- C23H37NO10
- MW:
- 487.54
- Product Categories:
-
- peg
- Mol File:
- 1334177-80-8.mol
More
Less
Cbz-N-amido-PEG6-acid Chemical Properties
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- color
- Colorless to light yellow
More
Less
Cbz-N-amido-PEG6-acid Usage And Synthesis
Description
Cbz-N-amido-PEG6-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions.
Uses
Cbz-NH-PEG6-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Cbz-N-amido-PEG6-acidSupplier
Alabiochem Tech.Co., Ltd.
- Tel
- 512-58900862 400-0707518
- sales@alabiochem.com
Chengdu Pukang Biotechnology Co., Ltd
- Tel
- +86-028-82550498 +86-19102685862
- sales@pu-kang.com
T&W GROUP
- Tel
- 021-61551611 13296011611
- contact@trustwe.com
Hunan HuaTeng Pharmaceutical Co., Ltd.,
- Tel
- 400-8592883
- sales@huatengsci.com
Shanghai Boka-chem Tech. Inc.
- Tel
- 400-026-1533/(021) 6478-0600
- sales@bokachem.com