Basic information Safety Supplier Related

O-PHOSPHO-D-SERINE

Basic information Safety Supplier Related

O-PHOSPHO-D-SERINE Basic information

Product Name:
O-PHOSPHO-D-SERINE
Synonyms:
  • D-2-AMINO-3-HYDROXYPROPANOIC ACID 3-PHOSPHATE
  • D-SERINE(PO3H2)-OH
  • D-SOP
  • H-D-SER(PO3H2)-OH
  • H-D-SER(H2PO3)-OH
  • O-PHOSPHO-D-SERINE
  • o-phospho-d-serinecrystalline
  • D-2-Amino-3-hydroxypropanoic acid 3-phosphate, D-SOP
CAS:
73913-63-0
MF:
C3H8NO6P
MW:
185.07
Product Categories:
  • SiChem
Mol File:
73913-63-0.mol
More
Less

O-PHOSPHO-D-SERINE Chemical Properties

storage temp. 
-15°C
solubility 
insoluble in DMSO; insoluble in EtOH; ≥18.5 mg/mL in H2O with gentle warming and ultrasonic
More
Less

O-PHOSPHO-D-SERINE Usage And Synthesis

Chemical Properties

White powder

Definition

ChEBI: O-phospho-D-serine is the D-enantiomer of O-phosphoserine. It is a conjugate acid of an O-phosphonatooxy-D-serine(2-). It is an enantiomer of an O-phospho-L-serine.

Biological Activity

o-phospho-d-serine is a weak agonist of the metabotropic glutamate receptor mglur4.mglur4 receptors, a member of the g protein-linked family of receptors for glutamate, are negatively coupled to camp. its expression is highest in granule cells of the cerebellum that send parallel fibers that synapse with purkinje cell dendrites.

in vitro

the affinity of l-serine-o-phosphate was examined in a baby hamster kidney cells expressing subtype mglur1 or mglur4 of the mglur family. results showed that both l-serine-o-phosphate or o-phospho-d-serine at 3 mm did not inhibit pi-hydrolysis as stimulated by 10 μm glutamate in bhk cells expressing mglur1. however, l-serine-o-phosphate was a potent agonist at the mglur4 subtype, which was negatively coupled to adenylate cyclase, while o-phospho-d-serine was found to be weakly active [1]. in another study, to test whether phosphatidylserine was recognized by amebae, calcium-treated cells were incubated with annexin v prior to adherence to or ingestion by e. histolytica. it was found that the coreceptor could be inhibited by phospho-l-serine and to a lesser extent by o-phospho-d-serine but not by phospho-l-threonine, which was consistent with the coreceptor functioning in the adherence and ingestion of erythrocytes via recognition of phosphatidylserine [2].

IC 50

1,260 μm for the metabotropic glutamate receptor mglur4

References

[1] thomsen, c. , and suzdak, p.d. serine-o-phosphate has affinity for type iv, but not type i, metabotropic glutamate receptor. neuroreport 4, 1099-1101 (1993).
[2] boettner, d. r.,huston, c.d.,sullivan, j.a., et al. entamoeba histolytica and entamoeba dispar utilize externalized phosphatidylserine for recognition and phagocytosis of erythrocytes. infection and immunity 73(6), 3422-3430 (2005).

O-PHOSPHO-D-SERINESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
T&W GROUP
Tel
021-61551611 13296011611
Email
contact@trustwe.com
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Email
sales@hopschem.com